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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6QZP

High-resolution cryo-EM structure of the human 80S ribosome

This is a non-PDB format compatible entry.
Replaces:  6EK0
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(L5)		28S rRNA (3773-MER)polymer37731223355.81Homo sapiens
2B
(L7)		5S rRNA (120-MER)polymer12038691.91GenBank (23898)Homo sapiens
3C
(L8)		5.8S rRNA (156-MER)polymer15650157.71Homo sapiens
4D
(LA)		60S ribosomal protein L8polymer24826998.61UniProt (P62917)
Pfam (PF00181)
Pfam (PF03947)		Homo sapiens (Human)Large ribosomal subunit protein uL2
5E
(LB)		60S ribosomal protein L3polymer40246079.91UniProt (P39023)
Pfam (PF00297)		Homo sapiens (Human)HIV-1 TAR RNA-binding protein B,TARBP-B,Large ribosomal subunit protein uL3
6F
(LC)		60S ribosomal protein L4polymer36841760.21UniProt (P36578)
Pfam (PF00573)
Pfam (PF14374)		Homo sapiens (Human)60S ribosomal protein L1,Large ribosomal subunit protein uL4
7G
(LD)		60S ribosomal protein L5polymer29334008.31UniProt (P46777)
Pfam (PF17144)
Pfam (PF14204)		Homo sapiens (Human)Large ribosomal subunit protein uL18
8H
(LE)		60S ribosomal protein L6polymer23627030.11UniProt (Q02878)
Pfam (PF03868)
Pfam (PF01159)		Homo sapiens (Human)Large ribosomal subunit protein eL6,Neoplasm-related protein C140,Tax-responsive enhancer element-binding protein 107,TaxREB107
9I
(LF)		60S ribosomal protein L7polymer22526590.71UniProt (P18124)
Pfam (PF08079)
Pfam (PF00327)		Homo sapiens (Human)Large ribosomal subunit protein uL30
10J
(LG)		60S ribosomal protein L7apolymer24127452.51UniProt (P62424)
Pfam (PF01248)		Homo sapiens (Human)Large ribosomal subunit protein eL8,PLA-X polypeptide,Surfeit locus protein 3
11K
(LH)		60S ribosomal protein L9polymer19021655.31UniProt (P32969)
Pfam (PF00347)		Homo sapiens (Human)Large ribosomal subunit protein uL6
12L
(LI)		60S ribosomal protein L10-likepolymer21324439.81UniProt (Q96L21)
Pfam (PF00252)		Homo sapiens (Human)Large ribosomal subunit protein uL16-like
13M
(LJ)		60S ribosomal protein L11polymer17620086.21UniProt (P62913)
Pfam (PF00281)
Pfam (PF00673)		Homo sapiens (Human)CLL-associated antigen KW-12,Large ribosomal subunit protein uL5
14N
(LL)		60S ribosomal protein L13polymer21024190.51UniProt (P26373)
Pfam (PF01294)		Homo sapiens (Human)Breast basic conserved protein 1,Large ribosomal subunit protein eL13
15O
(LM)		60S ribosomal protein L14polymer13916220.31UniProt (P50914)
Pfam (PF01929)		Homo sapiens (Human)CAG-ISL 7,Large ribosomal subunit protein eL14
16P
(LN)		60S ribosomal protein L15polymer20324076.11UniProt (P61313)
Pfam (PF00827)		Homo sapiens (Human)Large ribosomal subunit protein eL15
17Q
(LO)		60S ribosomal protein L13apolymer20123431.11UniProt (P40429)
Pfam (PF00572)		Homo sapiens (Human)23 kDa highly basic protein,Large ribosomal subunit protein uL13
18R
(LP)		60S ribosomal protein L17polymer15317757.61UniProt (P18621)
Pfam (PF00237)		Homo sapiens (Human)60S ribosomal protein L23,Large ribosomal subunit protein uL22,PD-1
19S
(LQ)		60S ribosomal protein L18polymer18721556.51UniProt (Q07020)
Pfam (PF17135)		Homo sapiens (Human)Large ribosomal subunit protein eL18
20T
(LR)		60S ribosomal protein L19polymer18722441.01UniProt (P84098)
Pfam (PF01280)
Pfam (PF25476)		Homo sapiens (Human)Large ribosomal subunit protein eL19
21U
(LS)		60S ribosomal protein L18apolymer17520677.31UniProt (Q02543)
Pfam (PF01775)		Homo sapiens (Human)Large ribosomal subunit protein eL20
22V
(LT)		60S ribosomal protein L21polymer15918478.81UniProt (P46778)
Pfam (PF01157)		Homo sapiens (Human)Large ribosomal subunit protein eL21
23W
(LU)		60S ribosomal protein L22polymer10111722.51UniProt (P35268)
Pfam (PF01776)		Homo sapiens (Human)EBER-associated protein,EAP,Epstein-Barr virus small RNA-associated protein,Heparin-binding protein HBp15,Large ribosomal subunit protein eL22
24X
(LV)		60S ribosomal protein L23polymer13113972.41UniProt (P62829)
Pfam (PF00238)		Homo sapiens (Human)60S ribosomal protein L17,Large ribosomal subunit protein uL14
25Y
(LW)		60S ribosomal protein L24polymer12414477.01UniProt (P83731)
Pfam (PF01246)		Homo sapiens (Human)60S ribosomal protein L30,Large ribosomal subunit protein eL24
26Z
(LX)		60S ribosomal protein L23apolymer12013985.51UniProt (P62750)
Pfam (PF03939)
Pfam (PF00276)		Homo sapiens (Human)Large ribosomal subunit protein uL23
27AA
(LY)		60S ribosomal protein L26polymer13415891.81UniProt (P61254)
Pfam (PF16906)
Pfam (PF00467)		Homo sapiens (Human)Large ribosomal subunit protein uL24
28BA
(LZ)		60S ribosomal protein L27polymer13515704.61UniProt (P61353)
Pfam (PF00467)
Pfam (PF01777)		Homo sapiens (Human)Large ribosomal subunit protein eL27
29CA
(La)		60S ribosomal protein L27apolymer14716473.31UniProt (P46776)
Pfam (PF00828)		Homo sapiens (Human)Large ribosomal subunit protein uL15
30DA
(Lb)		60S ribosomal protein L29polymer10912602.11UniProt (P47914)
Pfam (PF01779)		Homo sapiens (Human)Cell surface heparin-binding protein HIP,Large ribosomal subunit protein eL29
31EA
(Lc)		60S ribosomal protein L30polymer9810954.91UniProt (P62888)
Pfam (PF01248)		Homo sapiens (Human)Large ribosomal subunit protein eL30
32FA
(Ld)		60S ribosomal protein L31polymer10712635.71UniProt (P62899)
Pfam (PF01198)		Homo sapiens (Human)Large ribosomal subunit protein eL31
33GA
(Le)		60S ribosomal protein L32polymer12815022.01UniProt (P62910)
Pfam (PF01655)		Homo sapiens (Human)Large ribosomal subunit protein eL32
34HA
(Lf)		60S ribosomal protein L35apolymer10912433.51UniProt (P18077)
Pfam (PF01247)		Homo sapiens (Human)Cell growth-inhibiting gene 33 protein,Large ribosomal subunit protein eL33
35IA
(Lg)		60S ribosomal protein L34polymer11412994.61UniProt (P49207)
Pfam (PF01199)		Homo sapiens (Human)Large ribosomal subunit protein eL34
36JA
(Lh)		60S ribosomal protein L35polymer12214462.41UniProt (P42766)
Pfam (PF00831)		Homo sapiens (Human)Large ribosomal subunit protein uL29
37KA
(Li)		60S ribosomal protein L36polymer10211915.41UniProt (Q9Y3U8)
Pfam (PF01158)		Homo sapiens (Human)Large ribosomal subunit protein eL36
38LA
(Lj)		60S ribosomal protein L37polymer8610090.91UniProt (P61927)
Pfam (PF01907)		Homo sapiens (Human)G1.16,Large ribosomal subunit protein eL37
39MA
(Lk)		60S ribosomal protein L38polymer698107.81UniProt (P63173)
Pfam (PF01781)		Homo sapiens (Human)Large ribosomal subunit protein eL38
40NA
(Ll)		60S ribosomal protein L39polymer506295.61UniProt (P62891)
Pfam (PF00832)		Homo sapiens (Human)Large ribosomal subunit protein eL39
41OA
(Lm)		Ubiquitin-60S ribosomal protein L40polymer526212.61UniProt (P62987)
Pfam (PF01020)		Homo sapiens (Human)CEP52,Ubiquitin A-52 residue ribosomal protein fusion product 1
42PA
(Ln)		60S ribosomal protein L41polymer243344.31UniProt (P62945)
Pfam (PF05162)		Homo sapiens (Human)HG12,Large ribosomal subunit protein eL41
43QA
(Lo)		60S ribosomal protein L36apolymer10512345.81UniProt (P83881)
Pfam (PF00935)		Homo sapiens (Human)60S ribosomal protein L44,Cell growth-inhibiting gene 15 protein,Cell migration-inducing gene 6 protein,Large ribosomal subunit protein eL42
44RA
(Lp)		60S ribosomal protein L37apolymer9110168.21UniProt (P61513)
Pfam (PF01780)		Homo sapiens (Human)Large ribosomal subunit protein eL43
45SA
(Lr)		60S ribosomal protein L28polymer12514320.81UniProt (P46779)
Pfam (PF01778)		Homo sapiens (Human)Large ribosomal subunit protein eL28
46TA
(Lz)		60S ribosomal protein L10apolymer21724879.41UniProt (P62906)
Pfam (PF00687)		Homo sapiens (Human)CSA-19,Large ribosomal subunit protein uL1,Neural precursor cell expressed developmentally down-regulated protein 6,NEDD-6
47UA
(S2)		18S rRNA (1740-MER)polymer1740561898.21Homo sapiens
48VA
(S6)		E site tRNA (75-MER)polymer7524231.51GenBank (174924)Homo sapiens
49WA
(SA)		40S ribosomal protein SApolymer22124774.41UniProt (P08865)
Pfam (PF00318)		Homo sapiens (Human)37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,Small ribosomal subunit protein uS2
50XA
(SB)		40S ribosomal protein S3apolymer21424888.31UniProt (P61247)
Pfam (PF01015)		Homo sapiens (Human)Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1
51YA
(SD)		40S ribosomal protein S3polymer22725172.61UniProt (P23396)
Pfam (PF07650)
Pfam (PF00189)		Homo sapiens (Human)Small ribosomal subunit protein uS3
52ZA
(SE)		40S ribosomal protein S4, X isoformpolymer26229523.71UniProt (P62701)
Pfam (PF08071)
Pfam (PF00900)
Pfam (PF00467)
Pfam (PF16121)		Homo sapiens (Human)SCR10,Single copy abundant mRNA protein,Small ribosomal subunit protein eS4
53AB
(SF)		40S ribosomal protein S5polymer18921327.71UniProt (P46782)
Pfam (PF00177)		Homo sapiens (Human)Small ribosomal subunit protein uS7
54BB
(SH)		40S ribosomal protein S7polymer18621257.91UniProt (P62081)
Pfam (PF01251)		Homo sapiens (Human)Small ribosomal subunit protein eS7
55CB
(SI)		40S ribosomal protein S8polymer20624003.01UniProt (P62241)
Pfam (PF01201)		Homo sapiens (Human)Small ribosomal subunit protein eS8
56DB
(SK)		40S ribosomal protein S10polymer9811774.01UniProt (P46783)
Pfam (PF03501)		Homo sapiens (Human)Small ribosomal subunit protein eS10
57EB
(SL)		40S ribosomal protein S11polymer15317786.01UniProt (P62280)
Pfam (PF16205)
Pfam (PF00366)		Homo sapiens (Human)Small ribosomal subunit protein uS17
58FB
(SP)		40S ribosomal protein S15polymer12714931.61UniProt (P62841)
Pfam (PF00203)		Homo sapiens (Human)RIG protein,Small ribosomal subunit protein uS19
59GB
(SQ)		40S ribosomal protein S16polymer14115975.81UniProt (P62249)
Pfam (PF00380)		Homo sapiens (Human)Small ribosomal subunit protein uS9
60HB
(SR)		40S ribosomal protein S17polymer13515578.21UniProt (P08708)
Pfam (PF00833)		Homo sapiens (Human)Small ribosomal subunit protein eS17
61IB
(SS)		40S ribosomal protein S18polymer14517029.81UniProt (P62269)
Pfam (PF00416)		Homo sapiens (Human)Ke-3,Ke3,Small ribosomal subunit protein uS13
62JB
(ST)		40S ribosomal protein S19polymer14315822.21UniProt (P39019)
Pfam (PF01090)		Homo sapiens (Human)Small ribosomal subunit protein eS19
63KB
(SU)		40S ribosomal protein S20polymer10311694.81UniProt (P60866)
Pfam (PF00338)		Homo sapiens (Human)Small ribosomal subunit protein uS10
64LB
(SV)		40S ribosomal protein S21polymer839124.41UniProt (P63220)
Pfam (PF01249)		Homo sapiens (Human)Small ribosomal subunit protein eS21
65MB
(SX)		40S ribosomal protein S23polymer14115626.41UniProt (P62266)
Pfam (PF00164)		Homo sapiens (Human)Small ribosomal subunit protein uS12
66NB
(Sa)		40S ribosomal protein S26polymer10211742.91UniProt (P62854)
Pfam (PF01283)		Homo sapiens (Human)Small ribosomal subunit protein eS26
67OB
(Sc)		40S ribosomal protein S28polymer647263.41UniProt (P62857)
Pfam (PF01200)		Homo sapiens (Human)Small ribosomal subunit protein eS28
68PB
(Sd)		40S ribosomal protein S29polymer556559.61UniProt (P62273)
Pfam (PF00253)		Homo sapiens (Human)Small ribosomal subunit protein uS14
69QB
(Sg)		Receptor of activated protein C kinase 1polymer31334669.11UniProt (P63244)
Pfam (PF00400)		Homo sapiens (Human)Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1
70RB
(SC)		40S ribosomal protein S2polymer22224587.01UniProt (P15880)
Pfam (PF00333)
Pfam (PF03719)		Homo sapiens (Human)40S ribosomal protein S4,Protein LLRep3,Small ribosomal subunit protein uS5
71SB
(SG)		40S ribosomal protein S6polymer23727471.51UniProt (P62753)
Pfam (PF01092)		Homo sapiens (Human)Phosphoprotein NP33,Small ribosomal subunit protein eS6
72TB
(SJ)		40S ribosomal protein S9polymer18521649.61UniProt (P46781)
Pfam (PF00163)
Pfam (PF01479)		Homo sapiens (Human)Small ribosomal subunit protein uS4
73UB
(SM)		40S ribosomal protein S12polymer12213652.01UniProt (P25398)
Pfam (PF01248)		Homo sapiens (Human)Small ribosomal subunit protein eS12
74VB
(SN)		40S ribosomal protein S13polymer15017128.21UniProt (P62277)
Pfam (PF08069)
Pfam (PF00312)		Homo sapiens (Human)Small ribosomal subunit protein uS15
75WB
(SO)		40S ribosomal protein S14polymer14015014.21UniProt (P62263)
Pfam (PF00411)		Homo sapiens (Human)Small ribosomal subunit protein uS11
76XB
(SW)		40S ribosomal protein S15apolymer12914734.41UniProt (P62244)
Pfam (PF00410)		Homo sapiens (Human)Small ribosomal subunit protein uS8
77YB
(SY)		40S ribosomal protein S24polymer13115203.01UniProt (P62847)
Pfam (PF01282)		Homo sapiens (Human)Small ribosomal subunit protein eS24
78ZB
(SZ)		40S ribosomal protein S25polymer758526.11UniProt (P62851)
Pfam (PF03297)		Homo sapiens (Human)Small ribosomal subunit protein eS25
79AC
(Sb)		40S ribosomal protein S27polymer839349.01UniProt (P42677)
Pfam (PF01667)		Homo sapiens (Human)Metallopan-stimulin 1,MPS-1,Small ribosomal subunit protein eS27
80BC
(Se)		40S ribosomal protein S30polymer586539.81UniProt (P62861)
Pfam (PF04758)		Homo sapiens (Human)Small ribosomal subunit protein eS30
81CC
(Sf)		Ubiquitin-40S ribosomal protein S27apolymer677884.31UniProt (P62979)
Pfam (PF01599)		Homo sapiens (Human)Ubiquitin carboxyl extension protein 80
82AD, AE, AF, AG, AH...
(L5, L8, S2, SF, LA...)		MAGNESIUM IONnon-polymer24.3438Chemie (MG)
PubChem (888)
83QM
(L5)		(3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxinenon-polymer545.61Chemie (HMT)
PubChem (3628)
PubChem (285033)
PubChem (5458297)
PubChem (6604865)
PubChem (10951700)
PubChem (14368099)
PubChem (14368100)
PubChem (45356872)
PubChem (56841046)
PubChem (60128444)
PubChem (71211769)
PubChem (72332)
PubChem (53298607)
PubChem (93956057)
PubChem (138107280)
PubChem (58786313)
PubChem (60128438)
PubChem (68337922)
PubChem (70826802)
PubChem (70826803)
PubChem (71296925)
PubChem (90392075)
PubChem (92850103)
PubChem (92850104)
PubChem (93956055)
PubChem (93956056)
PubChem (93956058)
PubChem (118911842)
PubChem (140440283)
84GT, HT, IT, PN, QN...
(Sa, Sd, Sf, Lg, Lj...)		ZINC IONnon-polymer65.48Chemie (ZN)
85CT
(S2)		HYGROMYCIN Bnon-polymer527.51Chemie (HYG)
PubChem (446111)
PubChem (3068367)
PubChem (16219464)
PubChem (20054887)
PubChem (44120020)
PubChem (20054942)
PubChem (23777801)
PubChem (24875318)
PubChem (46943429)
PubChem (53393586)
PubChem (56928061)
PubChem (176519971)
PubChem (3659)
PubChem (35766)
PubChem (76971015)
PubChem (76971016)
PubChem (502206)
PubChem (52949613)
PubChem (91617579)
PubChem (53315786)
PubChem (98048103)
PubChem (5460094)
PubChem (124809074)
PubChem (124809080)
PubChem (125461707)
PubChem (129606984)
PubChem (131632475)
PubChem (57511216)
PubChem (134693050)
PubChem (58160574)
PubChem (13036911)
PubChem (139026182)
PubChem (139595130)
PubChem (146027508)
PubChem (162883455)
PubChem (162883447)
PubChem (162883454)
PubChem (168314873)
PubChem (71571512)
PubChem (76336793)
PubChem (89936880)
PubChem (90488914)
PubChem (93974294)
PubChem (94865124)
PubChem (94865125)
PubChem (96327587)
PubChem (96327588)
PubChem (98048102)
PubChem (101828545)
PubChem (117683867)
PubChem (118039329)
PubChem (118318030)
PubChem (124328800)
PubChem (124433112)
PubChem (124524088)
PubChem (124524089)
PubChem (124809075)
PubChem (124809078)
PubChem (125461706)
PubChem (125461708)
PubChem (129010089)
PubChem (129606985)
PubChem (134129613)
PubChem (138107735)
PubChem (138319323)
PubChem (139595131)
PubChem (145944872)
PubChem (146027509)
PubChem (146158568)
PubChem (154825180)
PubChem (157209529)
PubChem (160508452)
PubChem (160508454)
PubChem (162883446)
PubChem (162883448)
PubChem (162883449)
PubChem (162883450)
PubChem (162883451)
PubChem (162883452)
PubChem (162883453)
PubChem (168911900)
PubChem (169442324)
PubChem (172878373)
PubChem (173721900)
86AU, BU, CU, DU, EU...
(SS, SV, SC, SG, SN...)		waterwater18.044Chemie (HOH)
Sequence modifications
LE: 42 - 288 (UniProt: Q02878)
PDBExternal DatabaseDetails
-Lys 77deletion
-Ser 78deletion
-Lys 79deletion
-Val 80deletion
-Glu 81deletion
-Lys 82deletion
-Lys 83deletion
-Lys 84deletion
-Lys 85deletion
-Glu 86deletion
-Lys 87deletion
Lb: 2 - 122 (UniProt: P47914)
PDBExternal DatabaseDetails
-Lys 77deletion
-Pro 78deletion
-Lys 79deletion
-Glu 80deletion
-Val 81deletion
-Lys 82deletion
-Pro 83deletion
-Lys 84deletion
-Ile 85deletion
-Pro 86deletion
-Lys 87deletion
-Gly 88deletion
Ala 89Val 89conflict
SH: 5 - 193 (UniProt: P62081)
PDBExternal DatabaseDetails
-Ser 108deletion
-Arg 109deletion
-Thr 110deletion
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains81
Total formula weight3242543.8
Non-Polymers*Number of molecules448
Total formula weight12242.0
All*Total formula weight3254785.8
*Water molecules are not included.

251801

PDB entries from 2026-04-08

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