6QYQ
Crystal structure of human thymidylate synthase (hTS) variant R175C
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Thymidylate synthase | polymer | 325 | 37252.6 | 1 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens (Human) | TSase |
2 | C | Thymidylate synthase | polymer | 325 | 37298.6 | 1 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens (Human) | TSase |
3 | B | Thymidylate synthase | polymer | 325 | 37298.7 | 1 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens (Human) | TSase |
4 | D | Thymidylate synthase | polymer | 325 | 37252.6 | 1 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens (Human) | TSase |
5 | A, C, B, D | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
6 | A, C, B | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
7 | B, D | N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid | non-polymer | 473.4 | 2 | Chemie (FFO) | |||
8 | water | water | 18.0 | 474 | Chemie (HOH) |
Sequence modifications
A: 1 - 313 (UniProt: P04818)
C: 1 - 313 (UniProt: P04818)
B: 1 - 313 (UniProt: P04818)
D: 1 - 313 (UniProt: P04818)
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
Arg -10 | - | expression tag |
Gly -9 | - | expression tag |
Ser -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Cys 175 | Arg 175 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
Arg -10 | - | expression tag |
Gly -9 | - | expression tag |
Ser -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Cys 175 | Arg 175 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
Arg -10 | - | expression tag |
Gly -9 | - | expression tag |
Ser -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Cys 175 | Arg 175 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
Arg -10 | - | expression tag |
Gly -9 | - | expression tag |
Ser -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Cys 175 | Arg 175 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 149102.6 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1665.1 | |
All* | Total formula weight | 150767.6 |