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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6QYQ

Crystal structure of human thymidylate synthase (hTS) variant R175C

Functional Information from GO Data
ChainGOidnamespacecontents
A0000900molecular_functionmRNA regulatory element binding translation repressor activity
A0004799molecular_functionthymidylate synthase activity
A0005515molecular_functionprotein binding
A0005542molecular_functionfolic acid binding
A0005634cellular_componentnucleus
A0005657cellular_componentreplication fork
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006231biological_processdTMP biosynthetic process
A0006235biological_processdTTP biosynthetic process
A0006260biological_processDNA replication
A0008168molecular_functionmethyltransferase activity
A0009165biological_processnucleotide biosynthetic process
A0016740molecular_functiontransferase activity
A0016741molecular_functiontransferase activity, transferring one-carbon groups
A0017148biological_processnegative regulation of translation
A0032259biological_processmethylation
A0035999biological_processtetrahydrofolate interconversion
A0046653biological_processtetrahydrofolate metabolic process
A0071897biological_processDNA biosynthetic process
A1990825molecular_functionsequence-specific mRNA binding
B0000900molecular_functionmRNA regulatory element binding translation repressor activity
B0004799molecular_functionthymidylate synthase activity
B0005515molecular_functionprotein binding
B0005542molecular_functionfolic acid binding
B0005634cellular_componentnucleus
B0005657cellular_componentreplication fork
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005743cellular_componentmitochondrial inner membrane
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
B0006231biological_processdTMP biosynthetic process
B0006235biological_processdTTP biosynthetic process
B0006260biological_processDNA replication
B0008168molecular_functionmethyltransferase activity
B0009165biological_processnucleotide biosynthetic process
B0016740molecular_functiontransferase activity
B0016741molecular_functiontransferase activity, transferring one-carbon groups
B0017148biological_processnegative regulation of translation
B0032259biological_processmethylation
B0035999biological_processtetrahydrofolate interconversion
B0046653biological_processtetrahydrofolate metabolic process
B0071897biological_processDNA biosynthetic process
B1990825molecular_functionsequence-specific mRNA binding
C0000900molecular_functionmRNA regulatory element binding translation repressor activity
C0004799molecular_functionthymidylate synthase activity
C0005515molecular_functionprotein binding
C0005542molecular_functionfolic acid binding
C0005634cellular_componentnucleus
C0005657cellular_componentreplication fork
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005743cellular_componentmitochondrial inner membrane
C0005759cellular_componentmitochondrial matrix
C0005829cellular_componentcytosol
C0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
C0006231biological_processdTMP biosynthetic process
C0006235biological_processdTTP biosynthetic process
C0006260biological_processDNA replication
C0008168molecular_functionmethyltransferase activity
C0009165biological_processnucleotide biosynthetic process
C0016740molecular_functiontransferase activity
C0016741molecular_functiontransferase activity, transferring one-carbon groups
C0017148biological_processnegative regulation of translation
C0032259biological_processmethylation
C0035999biological_processtetrahydrofolate interconversion
C0046653biological_processtetrahydrofolate metabolic process
C0071897biological_processDNA biosynthetic process
C1990825molecular_functionsequence-specific mRNA binding
D0000900molecular_functionmRNA regulatory element binding translation repressor activity
D0004799molecular_functionthymidylate synthase activity
D0005515molecular_functionprotein binding
D0005542molecular_functionfolic acid binding
D0005634cellular_componentnucleus
D0005657cellular_componentreplication fork
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005743cellular_componentmitochondrial inner membrane
D0005759cellular_componentmitochondrial matrix
D0005829cellular_componentcytosol
D0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
D0006231biological_processdTMP biosynthetic process
D0006235biological_processdTTP biosynthetic process
D0006260biological_processDNA replication
D0008168molecular_functionmethyltransferase activity
D0009165biological_processnucleotide biosynthetic process
D0016740molecular_functiontransferase activity
D0016741molecular_functiontransferase activity, transferring one-carbon groups
D0017148biological_processnegative regulation of translation
D0032259biological_processmethylation
D0035999biological_processtetrahydrofolate interconversion
D0046653biological_processtetrahydrofolate metabolic process
D0071897biological_processDNA biosynthetic process
D1990825molecular_functionsequence-specific mRNA binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue SO4 A 401
ChainResidue
APRO193
AARG215
AHOH505
AHOH508
BARG176
site_idAC2
Number of Residues3
Detailsbinding site for residue SO4 A 402
ChainResidue
AARG78
APRO305
ATHR306
site_idAC3
Number of Residues4
Detailsbinding site for residue SO4 A 403
ChainResidue
AARG274
AHIS304
AHOH503
AGLU272
site_idAC4
Number of Residues2
Detailsbinding site for residue CL A 404
ChainResidue
AARG147
ASER151
site_idAC5
Number of Residues3
Detailsbinding site for residue SO4 C 401
ChainResidue
CARG215
CHOH511
DARG176
site_idAC6
Number of Residues2
Detailsbinding site for residue CL C 402
ChainResidue
CARG147
CSER151
site_idAC7
Number of Residues1
Detailsbinding site for residue CL C 403
ChainResidue
CTHR306
site_idAC8
Number of Residues5
Detailsbinding site for residue SO4 B 401
ChainResidue
ACYS175
AARG176
BARG50
BCSX195
BARG215
site_idAC9
Number of Residues14
Detailsbinding site for residue FFO B 402
ChainResidue
BPHE80
BILE108
BASN112
BLEU192
BASP218
BLEU221
BGLY222
BPHE225
BASN226
BMET311
BALA312
BHOH514
BHOH528
BHOH539
site_idAD1
Number of Residues1
Detailsbinding site for residue CL B 403
ChainResidue
DARG25
site_idAD2
Number of Residues5
Detailsbinding site for residue SO4 D 401
ChainResidue
CCYS175
CARG176
DCSX195
DARG215
DHOH547
site_idAD3
Number of Residues15
Detailsbinding site for residue FFO D 402
ChainResidue
DPHE80
DILE108
DASN112
DLEU192
DASP218
DLEU221
DGLY222
DPHE225
DASN226
DMET311
DALA312
DHOH505
DHOH520
DHOH535
DHOH544
Functional Information from PROSITE/UniProt
site_idPS00091
Number of Residues28
DetailsTHYMIDYLATE_SYNTHASE Thymidylate synthase active site. RiiMca.WNprdlplma.....LpPCHalcQFyV
ChainResidueDetails
DARG176-VAL203
BARG176-VAL203
AARG176-VAL203
CARG176-VAL203
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"P0A884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P45352","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues20
DetailsBinding site: {"description":"in other chain","evidences":[{"source":"UniProtKB","id":"P45352","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P0A884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues7
DetailsBinding site: {"description":"in other chain","evidences":[{"source":"UniProtKB","id":"P0A884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues12
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

248335

PDB entries from 2026-01-28

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