6QU5

Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an allosteric inhibitor ctcb12

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	ATP-dependent 6-phosphofructokinase	polymer	507	55764.7	8	UniProt (O15648) Pfam (PF00365) In PDB	Trypanosoma brucei brucei	Phosphofructokinase,Phosphohexokinase
2	A, B, C, D, E...	CITRIC ACID	non-polymer		192.1	8	Chemie (CIT)
3	A, B	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
4	A, B	1-[(3,4-dichlorophenyl)methyl]imidazole	non-polymer		227.1	2	Chemie (JJ8)

Sequence modifications

A, B, C, D, E, F, G, H: 1 - 487 (UniProt: O15648)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	446117.7
Non-Polymers*	Number of molecules	12
	Total formula weight	2175.4
All*	Total formula weight	448293.0

*Water molecules are not included.