6QS4
Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Chaperone protein ClpB | polymer | 858 | 95708.1 | 6 | UniProt (E0J719) Pfam (PF02861) Pfam (PF00004) Pfam (PF17871) Pfam (PF07724) Pfam (PF10431) | Escherichia coli (strain ATCC 9637 / CCM 2024 / DSM 1116 / NCIMB 8666 / NRRL B-766 / W) | |
| 2 | G (S) | casein | polymer | 24 | 1723.9 | 1 | Bos taurus | ||
| 3 | H, I, K, L, M... (A, B, C, D, E) | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | non-polymer | 523.2 | 9 | Chemie (AGS) | |||
| 4 | J, R (B, F) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) |
Sequence modifications
A, B, C, D, E, F: 1 - 857 (UniProt: E0J719)
| PDB | External Database | Details |
|---|---|---|
| Ala 279 | Glu 279 | engineered mutation |
| Cys 476 | Lys 476 | engineered mutation |
| Ala 678 | Glu 678 | engineered mutation |
| His 858 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 575972.7 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 5563.6 | |
| All* | Total formula weight | 581536.3 |
