6QPW
Structural basis of cohesin ring opening
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Structural maintenance of chromosomes protein,Structural maintenance of chromosomes protein | polymer | 242 | 27570.5 | 1 | UniProt (G0SGH3) | Chaetomium thermophilum var. thermophilum DSM 1495 | |
| 2 | B (B) | Sister chromatid cohesion protein 1 | polymer | 85 | 9489.9 | 1 | UniProt (Q12158) Pfam (PF04824) | Saccharomyces cerevisiae S288C | |
| 3 | C (C) | Structural maintenance of chromosomes protein 3,Structural maintenance of chromosomes protein 3 | polymer | 535 | 61051.8 | 1 | UniProt (P47037) Pfam (PF02463) | Saccharomyces cerevisiae S288C | DA-box protein SMC3,DA-box protein SMC3 |
| 4 | D (E) | Sister chromatid cohesion protein 1,Structural maintenance of chromosomes protein | polymer | 372 | 42292.1 | 1 | UniProt (Q12158) UniProt (G0SGH3) Pfam (PF04825) | Saccharomyces cerevisiae S288C | |
| 5 | E, G (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | F, H (A, E) | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | non-polymer | 523.2 | 2 | Chemie (AGS) |
Sequence modifications
A: 1 - 159 (UniProt: G0SGH3)
A: 160 - 242 (UniProt: G0SGH3)
B: 481 - 564 (UniProt: Q12158)
C: 2 - 957 (UniProt: P47037)
C: 970 - 1230 (UniProt: P47037)
E: 899 - 1057 (UniProt: Q12158)
E: 1058 - 1264 (UniProt: G0SGH3)
A: 160 - 242 (UniProt: G0SGH3)
B: 481 - 564 (UniProt: Q12158)
| PDB | External Database | Details |
|---|---|---|
| Met 480 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ala 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 958 | - | linker |
| Ser 959 | - | linker |
| Lys 960 | - | linker |
| His 961 | - | linker |
| Pro 962 | - | linker |
| Thr 963 | - | linker |
| Ser 964 | - | linker |
| Leu 965 | - | linker |
| Val 966 | - | linker |
| Pro 967 | - | linker |
| Arg 968 | - | linker |
| Gly 969 | - | linker |
| Cys 1159 | Ala 1159 | engineered mutation |
| Cys 1204 | Asn 1204 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 954 | Cys 56 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Cys 1160 | Leu 1160 | engineered mutation |
| Cys 1201 | Ala 1201 | engineered mutation |
| His 1265 | - | expression tag |
| His 1266 | - | expression tag |
| His 1267 | - | expression tag |
| His 1268 | - | expression tag |
| His 1269 | - | expression tag |
| His 1270 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 140404.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1095.1 | |
| All* | Total formula weight | 141499.4 |
