6QPW

Structural basis of cohesin ring opening

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0007062	biological_process	sister chromatid cohesion
A	0008278	cellular_component	cohesin complex
A	0016887	molecular_function	ATP hydrolysis activity
C	0005524	molecular_function	ATP binding
C	0016887	molecular_function	ATP hydrolysis activity
E	0005524	molecular_function	ATP binding
E	0007062	biological_process	sister chromatid cohesion
E	0008278	cellular_component	cohesin complex
E	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue MG A 301

Chain	Residue
A	SER40
A	GLN177
A	AGS302

---

site_id	AC2
Number of Residues	21
Details	binding site for residue AGS A 302

Chain	Residue
A	GLY38
A	LYS39
A	SER40
A	ASN41
A	ASP64
A	ILE66
A	ARG68
A	GLN177
A	MG301
C	GLN1125
C	LEU1126
C	SER1127
C	GLY1129
E	GLU1198
E	ARG1246
A	LYS13
A	SER14
A	PRO34
A	ASN35
A	GLY36
A	SER37

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MG E 1301

Chain	Residue
C	SER39
C	GLN148
E	AGS1302

---

site_id	AC4
Number of Residues	19
Details	binding site for residue AGS E 1302

Chain	Residue
C	LYS12
C	ASN34
C	GLY35
C	SER36
C	GLY37
C	LYS38
C	SER39
C	ASN40
C	GLY63
C	ILE65
C	GLN67
C	GLN148
C	LYS1205
E	LYS1161
E	HIS1168
E	SER1170
E	GLY1171
E	GLY1172
E	MG1301

---

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGEKTMAALALLF

Chain	Residue	Details
E	LEU1169-PHE1183

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
C	GLY32

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18614053

Chain	Residue	Details
C	LYS112
C	LYS113

---