6QPG

Influenza A virus Polymerase Heterotrimer A/nt/60/1968(H3N2) in complex with Nanobody NB8205

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (A, D, G, J)	Polymerase acidic protein	polymer	716	83100.8	4	UniProt (P03434) Pfam (PF00603)	Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60))
2	B, E, H, K (B, E, H, K)	RNA-directed RNA polymerase catalytic subunit	polymer	757	86524.1	4	UniProt (P03432) Pfam (PF00602)	Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60))	Polymerase basic protein 1,PB1,RNA-directed RNA polymerase subunit P1
3	C, F, I, L (C, F, I, L)	Polymerase basic protein 2	polymer	765	86958.2	4	UniProt (P03429) Pfam (PF20947) Pfam (PF20948) Pfam (PF20949) Pfam (PF20950) Pfam (PF00604) Pfam (PF20951) Pfam (PF20952)	Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60))	RNA-directed RNA polymerase subunit P3
4	M, N, O, P (M, N, O, P)	Nanobody NB8205	polymer	134	14835.4	4		Camelidae

Sequence modifications

B, E, H, K: 1 - 757 (UniProt: P03432)

PDB	External Database	Details
Lys 577	Glu 577	conflict

C, F, I, L: 1 - 759 (UniProt: P03429)

PDB	External Database	Details
Glu 760	-	expression tag
Asn 761	-	expression tag
Leu 762	-	expression tag
Tyr 763	-	expression tag
Phe 764	-	expression tag
Gln 765	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	1085674.0
All*	Total formula weight	1085674.0

*Water molecules are not included.