6QPG

Influenza A virus Polymerase Heterotrimer A/nt/60/1968(H3N2) in complex with Nanobody NB8205

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004519	molecular_function	endonuclease activity
A	0006351	biological_process	DNA-templated transcription
A	0030430	cellular_component	host cell cytoplasm
A	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
A	0039694	biological_process	viral RNA genome replication
A	0042025	cellular_component	host cell nucleus
A	0046872	molecular_function	metal ion binding
A	0075526	biological_process	cap snatching
B	0000166	molecular_function	nucleotide binding
B	0001172	biological_process	RNA-templated transcription
B	0003723	molecular_function	RNA binding
B	0003968	molecular_function	RNA-dependent RNA polymerase activity
B	0006351	biological_process	DNA-templated transcription
B	0019083	biological_process	viral transcription
B	0030430	cellular_component	host cell cytoplasm
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
B	0039694	biological_process	viral RNA genome replication
B	0042025	cellular_component	host cell nucleus
C	0001172	biological_process	RNA-templated transcription
C	0003723	molecular_function	RNA binding
C	0003968	molecular_function	RNA-dependent RNA polymerase activity
C	0006351	biological_process	DNA-templated transcription
C	0006370	biological_process	7-methylguanosine mRNA capping
C	0019049	biological_process	virus-mediated perturbation of host defense response
C	0019083	biological_process	viral transcription
C	0033650	cellular_component	host cell mitochondrion
C	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
C	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
C	0039694	biological_process	viral RNA genome replication
C	0042025	cellular_component	host cell nucleus
C	0044423	cellular_component	virion component
C	0075526	biological_process	cap snatching
D	0003723	molecular_function	RNA binding
D	0004519	molecular_function	endonuclease activity
D	0006351	biological_process	DNA-templated transcription
D	0030430	cellular_component	host cell cytoplasm
D	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
D	0039694	biological_process	viral RNA genome replication
D	0042025	cellular_component	host cell nucleus
D	0046872	molecular_function	metal ion binding
D	0075526	biological_process	cap snatching
E	0000166	molecular_function	nucleotide binding
E	0001172	biological_process	RNA-templated transcription
E	0003723	molecular_function	RNA binding
E	0003968	molecular_function	RNA-dependent RNA polymerase activity
E	0006351	biological_process	DNA-templated transcription
E	0019083	biological_process	viral transcription
E	0030430	cellular_component	host cell cytoplasm
E	0034062	molecular_function	5'-3' RNA polymerase activity
E	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
E	0039694	biological_process	viral RNA genome replication
E	0042025	cellular_component	host cell nucleus
F	0001172	biological_process	RNA-templated transcription
F	0003723	molecular_function	RNA binding
F	0003968	molecular_function	RNA-dependent RNA polymerase activity
F	0006351	biological_process	DNA-templated transcription
F	0006370	biological_process	7-methylguanosine mRNA capping
F	0019049	biological_process	virus-mediated perturbation of host defense response
F	0019083	biological_process	viral transcription
F	0033650	cellular_component	host cell mitochondrion
F	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
F	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
F	0039694	biological_process	viral RNA genome replication
F	0042025	cellular_component	host cell nucleus
F	0044423	cellular_component	virion component
F	0075526	biological_process	cap snatching
G	0003723	molecular_function	RNA binding
G	0004519	molecular_function	endonuclease activity
G	0006351	biological_process	DNA-templated transcription
G	0030430	cellular_component	host cell cytoplasm
G	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
G	0039694	biological_process	viral RNA genome replication
G	0042025	cellular_component	host cell nucleus
G	0046872	molecular_function	metal ion binding
G	0075526	biological_process	cap snatching
H	0000166	molecular_function	nucleotide binding
H	0001172	biological_process	RNA-templated transcription
H	0003723	molecular_function	RNA binding
H	0003968	molecular_function	RNA-dependent RNA polymerase activity
H	0006351	biological_process	DNA-templated transcription
H	0019083	biological_process	viral transcription
H	0030430	cellular_component	host cell cytoplasm
H	0034062	molecular_function	5'-3' RNA polymerase activity
H	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
H	0039694	biological_process	viral RNA genome replication
H	0042025	cellular_component	host cell nucleus
I	0001172	biological_process	RNA-templated transcription
I	0003723	molecular_function	RNA binding
I	0003968	molecular_function	RNA-dependent RNA polymerase activity
I	0006351	biological_process	DNA-templated transcription
I	0006370	biological_process	7-methylguanosine mRNA capping
I	0019049	biological_process	virus-mediated perturbation of host defense response
I	0019083	biological_process	viral transcription
I	0033650	cellular_component	host cell mitochondrion
I	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
I	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
I	0039694	biological_process	viral RNA genome replication
I	0042025	cellular_component	host cell nucleus
I	0044423	cellular_component	virion component
I	0075526	biological_process	cap snatching
J	0003723	molecular_function	RNA binding
J	0004519	molecular_function	endonuclease activity
J	0006351	biological_process	DNA-templated transcription
J	0030430	cellular_component	host cell cytoplasm
J	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
J	0039694	biological_process	viral RNA genome replication
J	0042025	cellular_component	host cell nucleus
J	0046872	molecular_function	metal ion binding
J	0075526	biological_process	cap snatching
K	0000166	molecular_function	nucleotide binding
K	0001172	biological_process	RNA-templated transcription
K	0003723	molecular_function	RNA binding
K	0003968	molecular_function	RNA-dependent RNA polymerase activity
K	0006351	biological_process	DNA-templated transcription
K	0019083	biological_process	viral transcription
K	0030430	cellular_component	host cell cytoplasm
K	0034062	molecular_function	5'-3' RNA polymerase activity
K	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
K	0039694	biological_process	viral RNA genome replication
K	0042025	cellular_component	host cell nucleus
L	0001172	biological_process	RNA-templated transcription
L	0003723	molecular_function	RNA binding
L	0003968	molecular_function	RNA-dependent RNA polymerase activity
L	0006351	biological_process	DNA-templated transcription
L	0006370	biological_process	7-methylguanosine mRNA capping
L	0019049	biological_process	virus-mediated perturbation of host defense response
L	0019083	biological_process	viral transcription
L	0033650	cellular_component	host cell mitochondrion
L	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
L	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
L	0039694	biological_process	viral RNA genome replication
L	0042025	cellular_component	host cell nucleus
L	0044423	cellular_component	virion component
L	0075526	biological_process	cap snatching

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Mammalian adaptation => ECO:0000255|HAMAP-Rule:MF_04062

Chain	Residue	Details
A	ILE120
D	HIS41
D	GLU80
D	ASP108
D	GLU119
D	ILE120
G	HIS41
G	GLU80
G	ASP108
G	GLU119
G	ILE120
J	HIS41
J	GLU80
J	ASP108
J	GLU119
J	ILE120
C	LYS627
F	LYS627
I	LYS627
L	LYS627

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