6QMT
Complement factor D in complex with the inhibitor 2-(2-(3'-(aminomethyl)-[1,1'-biphenyl]-3-carboxamido)phenyl)acetic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Complement factor D | polymer | 254 | 27097.9 | 2 | UniProt (P00746) Pfam (PF00089) | Homo sapiens (Human) | Adipsin,C3 convertase activator,Properdin factor D |
| 2 | C, D (A, B) | 2-[2-[[3-[3-(aminomethyl)phenyl]phenyl]carbonylamino]phenyl]ethanoic acid | non-polymer | 360.4 | 2 | Chemie (J7B) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A, B: -8 - 243 (UniProt: P00746)
| PDB | External Database | Details |
|---|---|---|
| Ser 244 | - | expression tag |
| Ala 245 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54195.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 720.8 | |
| All* | Total formula weight | 54916.7 |
