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6QMT

Complement factor D in complex with the inhibitor 2-(2-(3'-(aminomethyl)-[1,1'-biphenyl]-3-carboxamido)phenyl)acetic acid

Experimental procedure
Experimental methodSINGLE WAVELENGTH
Source typeSYNCHROTRON
Source detailsSLS BEAMLINE X10SA
Synchrotron siteSLS
BeamlineX10SA
Temperature [K]100
Detector technologyPIXEL
Collection date2012-01-06
DetectorDECTRIS PILATUS 2M
Wavelength(s)1.000
Spacegroup nameP 1
Unit cell lengths37.964, 39.235, 63.502
Unit cell angles83.03, 75.34, 65.17
Refinement procedure
Resolution35.600 - 1.800
R-factor0.2035
Rwork0.202
R-free0.23120
Structure solution methodMOLECULAR REPLACEMENT
Starting model (for MR)1dsu
RMSD bond length0.016
RMSD bond angle1.921
Data reduction softwareXDS
Data scaling softwareXSCALE
Phasing softwarePHASER
Refinement softwareREFMAC (5.8.0238)
Data quality characteristics
 OverallOuter shell
Low resolution limit [Å]61.4101.730
High resolution limit [Å]1.6301.630
Rmerge0.0500.310
Rmeas0.0630.400
Number of reflections374035507
<I/σ(I)>10.932.49
Completeness [%]92.984.3
Redundancy2.352.15
Crystallization Conditions
crystal IDmethodpHtemperaturedetails
1VAPOR DIFFUSION, SITTING DROP5.529325% PEGME 3350, 100 mM Bis-Tris pH 5.5

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