6QFM
Structure of human Mcl-1 in complex with PUMA BH3 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 162 | 18352.9 | 1 | UniProt (Q07820) Pfam (PF00452) | Homo sapiens (Human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
| 2 | B (B) | Bcl-2-binding component 3 | polymer | 23 | 2748.0 | 1 | UniProt (Q9BXH1) | Homo sapiens | JFY-1,p53 up-regulated modulator of apoptosis |
| 3 | C, D, E (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | F, G, H (A, B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 83 | Chemie (HOH) |
Sequence modifications
A: 171 - 327 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly 166 | - | expression tag |
| Pro 167 | - | expression tag |
| Leu 168 | - | expression tag |
| Gly 169 | - | expression tag |
| Ser 170 | - | expression tag |
| Asp 173 | Glu 173 | engineered mutation |
| Gly 241 | Asp 241 | engineered mutation |
| Phe 246 | Leu 246 | engineered mutation |
| Val 251 | Ile 251 | engineered mutation |
| Lys 255 | Ser 255 | engineered mutation |
| Ser 280 | Thr 280 | engineered mutation |
| Val 281 | Ile 281 | engineered mutation |
| Phe 286 | Cys 286 | engineered mutation |
| Thr 293 | Ser 293 | engineered mutation |
| Gln 322 | Glu 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21100.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 302.6 | |
| All* | Total formula weight | 21403.4 |
