6QFF
Crystal Structure of Human Kallikrein 6 in complex with GSK144
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Kallikrein-6 | polymer | 222 | 24288.5 | 2 | UniProt (Q92876) Pfam (PF00089) | Homo sapiens (Human) | Neurosin,Protease M,SP59,Serine protease 18,Serine protease 9,Zyme |
| 2 | C, E (A, B) | 4-[(5-phenyl-1~{H}-imidazol-2-yl)methylamino]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide | non-polymer | 398.5 | 2 | Chemie (J08) | |||
| 3 | D (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 420 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 244 (UniProt: Q92876)
| PDB | External Database | Details |
|---|---|---|
| Gly 74 | Arg 78 | engineered mutation |
| Gln 76 | Arg 80 | engineered mutation |
| Gln 132 | Asn 134 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48577.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 889.0 | |
| All* | Total formula weight | 49466.0 |
