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6QFF

Crystal Structure of Human Kallikrein 6 in complex with GSK144

Functional Information from GO Data
ChainGOidnamespacecontents
A0001533cellular_componentcornified envelope
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0006508biological_processproteolysis
A0007417biological_processcentral nervous system development
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0009611biological_processresponse to wounding
A0010975biological_processregulation of neuron projection development
A0016540biological_processprotein autoprocessing
A0030141cellular_componentsecretory granule
A0030574biological_processcollagen catabolic process
A0031965cellular_componentnuclear membrane
A0042246biological_processtissue regeneration
A0042445biological_processhormone metabolic process
A0042552biological_processmyelination
A0042982biological_processamyloid precursor protein metabolic process
A0045171cellular_componentintercellular bridge
A0045595biological_processregulation of cell differentiation
A0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
B0001533cellular_componentcornified envelope
B0004252molecular_functionserine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005783cellular_componentendoplasmic reticulum
B0006508biological_processproteolysis
B0007417biological_processcentral nervous system development
B0008233molecular_functionpeptidase activity
B0008236molecular_functionserine-type peptidase activity
B0009611biological_processresponse to wounding
B0010975biological_processregulation of neuron projection development
B0016540biological_processprotein autoprocessing
B0030141cellular_componentsecretory granule
B0030574biological_processcollagen catabolic process
B0031965cellular_componentnuclear membrane
B0042246biological_processtissue regeneration
B0042445biological_processhormone metabolic process
B0042552biological_processmyelination
B0042982biological_processamyloid precursor protein metabolic process
B0045171cellular_componentintercellular bridge
B0045595biological_processregulation of cell differentiation
B0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue J08 A 301
ChainResidue
AHIS57
ATRP215
AGLY216
AASN217
AILE218
ACYS220
AHOH495
AHOH576
AHIS99
AASP189
ASER190
ACYS191
AGLN192
ASER195
AVAL213
ASER214

site_idAC2
Number of Residues9
Detailsbinding site for residue GOL B 301
ChainResidue
APRO92
AASP93
BTYR34
BPHE66
BLYS70
BLEU73
BHOH435
BHOH463
BHOH521

site_idAC3
Number of Residues19
Detailsbinding site for residue J08 B 302
ChainResidue
AGLY38
AHIS39
BHIS57
BTYR94
BHIS99
BASP189
BSER190
BCYS191
BGLN192
BSER195
BVAL213
BSER214
BTRP215
BGLY216
BASN217
BILE218
BCYS220
BHOH499
BHOH541

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
ChainResidueDetails
ALEU53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV
ChainResidueDetails
AASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Charge relay system => ECO:0000269|PubMed:12016211
ChainResidueDetails
AHIS57
AASP102
ASER195
BHIS57
BASP102
BSER195

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Cleavage; by autolysis
ChainResidueDetails
AGLN76
BGLN76

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AGLN132
BGLN132

226707

PDB entries from 2024-10-30

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