6QEJ

CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR Thiophene-2-sulfonic acid (4-fluoro-benzyl)-(4H-[1,2,4]triazol-3-ylmethyl)-amide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Methionine aminopeptidase 2	polymer	378	42470.2	1	UniProt (P50579) Pfam (PF00557) In PDB	Homo sapiens (Human)	MetAP 2,Initiation factor 2-associated 67 kDa glycoprotein,p67eIF2,Peptidase M
2	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
3	A	~{N}-[(4-fluorophenyl)methyl]-~{N}-(1~{H}-1,2,4-triazol-5-ylmethyl)thiophene-2-sulfonamide	non-polymer		352.4	1	Chemie (HZT)
4	A	TERTIARY-BUTYL ALCOHOL	non-polymer		74.1	1	Chemie (TBU)
5	A	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
6		water	water		18.0	447	Chemie (HOH)

Sequence modifications

A: 108 - 478 (UniProt: P50579)

PDB	External Database	Details
Met 107	-	initiating methionine
His 479	-	expression tag
His 480	-	expression tag
His 481	-	expression tag
His 482	-	expression tag
His 483	-	expression tag
His 484	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42470.2
Non-Polymers*	Number of molecules	5
	Total formula weight	598.5
All*	Total formula weight	43068.7

*Water molecules are not included.