6QEJ
CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR Thiophene-2-sulfonic acid (4-fluoro-benzyl)-(4H-[1,2,4]triazol-3-ylmethyl)-amide
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 501 |
| Chain | Residue |
| A | MET184 |
| A | PHE265 |
| A | ASP477 |
| A | HOH601 |
| A | HOH652 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue HZT A 502 |
| Chain | Residue |
| A | HIS331 |
| A | HIS339 |
| A | GLU364 |
| A | HIS382 |
| A | ALA414 |
| A | TYR444 |
| A | GLU459 |
| A | MN504 |
| A | MN505 |
| A | HOH624 |
| A | HIS231 |
| A | ASP251 |
| A | ASP262 |
| A | ASN329 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue TBU A 503 |
| Chain | Residue |
| A | PRO189 |
| A | TYR244 |
| A | TYR244 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MN A 504 |
| Chain | Residue |
| A | ASP262 |
| A | HIS331 |
| A | GLU364 |
| A | GLU459 |
| A | HZT502 |
| A | MN505 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 505 |
| Chain | Residue |
| A | ASP251 |
| A | ASP262 |
| A | GLU459 |
| A | HZT502 |
| A | MN504 |
Functional Information from PROSITE/UniProt
| site_id | PS01202 |
| Number of Residues | 17 |
| Details | MAP_2 Methionine aminopeptidase subfamily 2 signature. DIcKIDfGtHISGriiD |
| Chain | Residue | Details |
| A | ASP246-ASP262 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03175","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16540317","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03175","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14534293","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16134930","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16540317","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17350258","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17636946","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
