6QEI

CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR 5,6-Difluoro-3-(2-isopropoxy-4-piperazin-1-yl-phenyl)-1H-indole-2-carboxylic acid amide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Methionine aminopeptidase 2	polymer	378	42470.2	1	UniProt (P50579) Pfam (PF00557) In PDB	Homo sapiens (Human)	MetAP 2,Initiation factor 2-associated 67 kDa glycoprotein,p67eIF2,Peptidase M
2	A	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	A	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
5	A	5,6-bis(fluoranyl)-3-(4-piperazin-1-yl-2-propan-2-yloxy-phenyl)-1~{H}-indole-2-carboxamide	non-polymer		414.4	1	Chemie (HZE)
6	A	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
7		water	water		18.0	187	Chemie (HOH)

Sequence modifications

A: 108 - 478 (UniProt: P50579)

PDB	External Database	Details
Met 107	-	initiating methionine
His 479	-	expression tag
His 480	-	expression tag
His 481	-	expression tag
His 482	-	expression tag
His 483	-	expression tag
His 484	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42470.2
Non-Polymers*	Number of molecules	7
	Total formula weight	818.7
All*	Total formula weight	43288.9

*Water molecules are not included.