6QEI
CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR 5,6-Difluoro-3-(2-isopropoxy-4-piperazin-1-yl-phenyl)-1H-indole-2-carboxylic acid amide
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 501 |
| Chain | Residue |
| A | MET184 |
| A | THR266 |
| A | VAL267 |
| A | THR268 |
| A | LEU277 |
| A | HOH743 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | PHE265 |
| A | PHE458 |
| A | GLU459 |
| A | HIS460 |
| A | GOL503 |
| A | DMS504 |
| A | HOH690 |
| A | ARG180 |
| A | CYS263 |
| A | ALA264 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | ARG180 |
| A | HIS460 |
| A | ARG474 |
| A | GLY475 |
| A | EDO502 |
| A | DMS504 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 504 |
| Chain | Residue |
| A | ARG180 |
| A | MET184 |
| A | EDO502 |
| A | GOL503 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue HZE A 505 |
| Chain | Residue |
| A | PHE219 |
| A | PRO220 |
| A | HIS231 |
| A | ASP262 |
| A | HIS331 |
| A | HIS339 |
| A | GLU364 |
| A | HIS382 |
| A | MET384 |
| A | ALA414 |
| A | TYR444 |
| A | MN506 |
| A | HOH605 |
| A | HOH745 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue MN A 506 |
| Chain | Residue |
| A | ASP262 |
| A | HIS331 |
| A | GLU364 |
| A | GLU459 |
| A | HZE505 |
| A | MN507 |
| A | HOH605 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MN A 507 |
| Chain | Residue |
| A | ASP251 |
| A | ASP262 |
| A | GLU459 |
| A | MN506 |
| A | HOH605 |
| A | HOH745 |
Functional Information from PROSITE/UniProt
| site_id | PS01202 |
| Number of Residues | 17 |
| Details | MAP_2 Methionine aminopeptidase subfamily 2 signature. DIcKIDfGtHISGriiD |
| Chain | Residue | Details |
| A | ASP246-ASP262 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03175","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16540317","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03175","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14534293","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16134930","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16540317","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17350258","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17636946","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
