Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (2) | U2 snRNA | polymer | 189 | 60459.6 | 1 | Homo sapiens (Human) | ||
| 2 | B (5) | U5 snRNA | polymer | 116 | 36908.7 | 1 | GenBank (36515) | Homo sapiens (human) | |
| 3 | C (6) | U6 snRNA | polymer | 106 | 34098.3 | 1 | Homo sapiens (Human) | ||
| 4 | D (7) | Eukaryotic initiation factor 4A-III, N-terminally processed | polymer | 390 | 44691.4 | 1 | UniProt (P38919) Pfam (PF00270) Pfam (PF00271) | Homo sapiens (human) | |
| 5 | E (8) | RNA-binding protein 8A | polymer | 91 | 10370.5 | 1 | UniProt (Q9Y5S9) Pfam (PF00076) | Homo sapiens (human) | Binder of OVCA1-1,BOV-1,RNA-binding motif protein 8A,RNA-binding protein Y14,Ribonucleoprotein RBM8A |
| 6 | F (9) | Protein mago nashi homolog 2 | polymer | 144 | 16929.3 | 1 | UniProt (Q96A72) Pfam (PF02792) | Homo sapiens (human) | |
| 7 | G (A) | Pre-mRNA-processing-splicing factor 8 | polymer | 2335 | 273974.3 | 1 | UniProt (Q6P2Q9) Pfam (PF12134) Pfam (PF01398) Pfam (PF08084) Pfam (PF08082) Pfam (PF08083) Pfam (PF10598) Pfam (PF10597) Pfam (PF10596) | Homo sapiens (human) | 220 kDa U5 snRNP-specific protein,PRP8 homolog,Splicing factor Prp8,p220 |
| 8 | H (B) | U5 small nuclear ribonucleoprotein 200 kDa helicase | polymer | 1722 | 197054.0 | 1 | UniProt (O75643) Pfam (PF00270) Pfam (PF00271) Pfam (PF02889) | Homo sapiens (human) | Activating signal cointegrator 1 complex subunit 3-like 1,BRR2 homolog,U5 snRNP-specific 200 kDa protein,U5-200KD |
| 9 | I (C) | 116 kDa U5 small nuclear ribonucleoprotein component | polymer | 899 | 101231.9 | 1 | UniProt (Q15029) Pfam (PF16004) Pfam (PF00009) Pfam (PF03144) Pfam (PF14492) Pfam (PF03764) Pfam (PF00679) | Homo sapiens (human) | Elongation factor Tu GTP-binding domain-containing protein 2,SNU114 homolog,hSNU114,U5 snRNP-specific protein,116 kDa,U5-116 kDa |
| 10 | J (D) | PRKR-interacting protein 1 | polymer | 123 | 14476.9 | 1 | UniProt (Q9H875) Pfam (PF06658) | Homo sapiens (human) | |
| 11 | K (E) | Ligated exons: MINX mRNA | polymer | 14 | 4437.7 | 1 | Human adenovirus 2 | ||
| 12 | L (F) | Cactin | polymer | 122 | 15210.2 | 1 | UniProt (Q8WUQ7) Pfam (PF09732) | Homo sapiens (human) | Renal carcinoma antigen NY-REN-24 |
| 13 | M (G) | Protein FAM32A | polymer | 60 | 7269.4 | 1 | UniProt (Q9Y421) Pfam (PF08555) | Homo sapiens (human) | Ovarian tumor-associated gene 12,OTAG-12 |
| 14 | N (H) | Pre-mRNA-splicing factor CWC22 homolog | polymer | 908 | 105646.6 | 1 | UniProt (Q9HCG8) Pfam (PF02854) Pfam (PF02847) | Homo sapiens (human) | Nucampholin homolog,fSAPb |
| 15 | O (I) | Intron lariat: MINX RNA | polymer | 113 | 27772.0 | 1 | Human adenovirus 2 | ||
| 16 | P (J) | Pleiotropic regulator 1 | polymer | 320 | 35782.4 | 1 | UniProt (O43660) Pfam (PF00400) | Homo sapiens (human) | |
| 17 | Q (K) | SNW domain-containing protein 1 | polymer | 295 | 33819.9 | 1 | UniProt (Q13573) Pfam (PF02731) | Homo sapiens (human) | Nuclear protein SkiP,Nuclear receptor coactivator NCoA-62,Ski-interacting protein |
| 18 | R (L) | Protein BUD31 homolog | polymer | 144 | 17032.8 | 1 | UniProt (P41223) Pfam (PF01125) | Homo sapiens (human) | Protein EDG-2,Protein G10 homolog |
| 19 | S (M) | Pre-mRNA-splicing factor RBM22 | polymer | 289 | 33156.1 | 1 | UniProt (Q9NW64) Pfam (PF21369) Pfam (PF00076) | Homo sapiens (human) | RNA-binding motif protein 22,Zinc finger CCCH domain-containing protein 16 |
| 20 | T (N) | U5 small nuclear ribonucleoprotein 40 kDa protein | polymer | 306 | 34092.4 | 1 | UniProt (Q96DI7) Pfam (PF00400) | Homo sapiens (human) | U5-40K,38 kDa-splicing factor,Prp8-binding protein,hPRP8BP,U5 snRNP-specific 40 kDa protein,WD repeat-containing protein 57 |
| 21 | U (O) | Cell division cycle 5-like protein | polymer | 802 | 92406.9 | 1 | UniProt (Q99459) Pfam (PF13921) Pfam (PF11831) | Homo sapiens (human) | Cdc5-like protein,Pombe cdc5-related protein |
| 22 | V (P) | Spliceosome-associated protein CWC15 homolog | polymer | 229 | 26674.4 | 1 | UniProt (Q9P013) Pfam (PF04889) | Homo sapiens (human) | |
| 23 | W (R) | Serine/arginine repetitive matrix protein 2 | polymer | 26 | 2767.1 | 1 | UniProt (Q9UQ35) | Homo sapiens (human) | 300 kDa nuclear matrix antigen,Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa,Ser/Arg-related nuclear matrix protein of 300 kDa,Splicing coactivator subunit SRm300,Tax-responsive enhancer element-binding protein 803,TaxREB803 |
| 24 | X (S) | Crooked neck-like protein 1 | polymer | 848 | 100610.0 | 1 | UniProt (Q9BZJ0) Pfam (PF02184) | Homo sapiens (human) | Crooked neck homolog,hCrn |
| 25 | Y (T) | Pre-mRNA-splicing factor SYF1 | polymer | 855 | 100148.7 | 1 | UniProt (Q9HCS7) Pfam (PF13181) | Homo sapiens (human) | Protein HCNP,XPA-binding protein 2 |
| 26 | Z (U) | Intron-binding protein aquarius | polymer | 1485 | 171502.5 | 1 | UniProt (O60306) Pfam (PF16399) Pfam (PF21143) Pfam (PF21144) Pfam (PF13086) Pfam (PF13087) | Homo sapiens (human) | Intron-binding protein of 160 kDa,IBP160 |
| 27 | AA (V) | ATP-dependent RNA helicase DHX8 | polymer | 1220 | 139522.3 | 1 | UniProt (Q14562) Pfam (PF00575) Pfam (PF00270) Pfam (PF00271) Pfam (PF04408) Pfam (PF21010) Pfam (PF07717) | Homo sapiens (human) | DEAH box protein 8,RNA helicase HRH1 |
| 28 | BA (W) | U2 small nuclear ribonucleoprotein A' | polymer | 162 | 18697.7 | 1 | UniProt (P09661) Pfam (PF14580) | Homo sapiens (human) | U2 snRNP A' |
| 29 | CA (Y) | U2 small nuclear ribonucleoprotein B'' | polymer | 92 | 10688.6 | 1 | UniProt (P08579) Pfam (PF00076) | Homo sapiens (human) | U2 snRNP B'' |
| 30 | DA (Z) | NF-kappa-B-activating protein | polymer | 30 | 3321.8 | 1 | UniProt (Q8N5F7) | Homo sapiens (human) | |
| 31 | EA, NA (b, k) | Small nuclear ribonucleoprotein-associated proteins B and B' | polymer | 82 | 9551.3 | 2 | UniProt (P14678) Pfam (PF01423) | Homo sapiens (human) | snRNP-B,Sm protein B/B',SmB/B' |
| 32 | FA (c) | Pre-mRNA-splicing factor SLU7 | polymer | 586 | 68510.8 | 1 | UniProt (O95391) Pfam (PF11708) | Homo sapiens (human) | hSlu7 |
| 33 | GA, QA (d, n) | Small nuclear ribonucleoprotein Sm D3 | polymer | 84 | 9461.0 | 2 | UniProt (P62318) Pfam (PF01423) | Homo sapiens (human) | Sm-D3,snRNP core protein D3 |
| 34 | HA, SA (e, p) | Small nuclear ribonucleoprotein E | polymer | 81 | 9582.2 | 2 | UniProt (P62304) Pfam (PF01423) | Homo sapiens (human) | snRNP-E,Sm protein E,SmE |
| 35 | IA, TA (f, q) | Small nuclear ribonucleoprotein F | polymer | 72 | 8038.4 | 2 | UniProt (P62306) Pfam (PF01423) | Homo sapiens (human) | snRNP-F,Sm protein F,SmF |
| 36 | JA, UA (g, r) | Small nuclear ribonucleoprotein G | polymer | 73 | 8160.6 | 2 | UniProt (P62308) Pfam (PF01423) | Homo sapiens (human) | snRNP-G,Sm protein G,SmG |
| 37 | KA, OA (h, l) | Small nuclear ribonucleoprotein Sm D1 | polymer | 80 | 9086.7 | 2 | UniProt (P62314) Pfam (PF01423) | Homo sapiens (human) | Sm-D1,Sm-D autoantigen,snRNP core protein D1 |
| 38 | LA (i) | Peptidyl-prolyl cis-trans isomerase-like 1 | polymer | 164 | 18055.5 | 1 | UniProt (Q9Y3C6) Pfam (PF00160) | Homo sapiens (human) | PPIase,Rotamase PPIL1 |
| 39 | MA, PA (j, m) | Small nuclear ribonucleoprotein Sm D2 | polymer | 118 | 13551.9 | 2 | UniProt (P62316) Pfam (PF01423) | Homo sapiens (human) | Sm-D2,snRNP core protein D2 |
| 40 | RA (o) | Pre-mRNA-processing factor 17 | polymer | 513 | 59116.1 | 1 | UniProt (O60508) Pfam (PF00400) | Homo sapiens (human) | Cell division cycle 40 homolog,EH-binding protein 3,Ehb3,PRP17 homolog,hPRP17 |
| 41 | VA (s) | Pre-mRNA-splicing factor SPF27 | polymer | 225 | 26163.4 | 1 | UniProt (O75934) Pfam (PF05700) | Homo sapiens (human) | Breast carcinoma-amplified sequence 2,DNA amplified in mammary carcinoma 1 protein,Spliceosome-associated protein SPF 27 |
| 42 | WA, XA, YA, ZA (t, u, v, w) | Pre-mRNA-processing factor 19 | polymer | 504 | 55245.5 | 4 | UniProt (Q9UMS4) Pfam (PF04564) Pfam (PF08606) Pfam (PF00400) | Homo sapiens (human) | Nuclear matrix protein 200,PRP19/PSO4 homolog,hPso4,RING-type E3 ubiquitin transferase PRP19,Senescence evasion factor |
| 43 | AB (y) | Pre-mRNA-splicing factor SYF2 | polymer | 144 | 17302.4 | 1 | UniProt (O95926) Pfam (PF08231) | Homo sapiens (human) | CCNDBP1-interactor,p29 |
| 44 | BB (z) | Replication stress response regulator SDE2 | polymer | 34 | 4036.5 | 1 | UniProt (Q6IQ49) Pfam (PF22782) | Homo sapiens (human) | |
| 45 | CB, DB, EB, FB, GB... (6, 7, C) | MAGNESIUM ION | non-polymer | 24.3 | 7 | Chemie (MG) | |||
| 46 | HB (6) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 47 | JB (7) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 48 | KB (C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 49 | MB, NB, OB, PB, QB... (L, M, c) | ZINC ION | non-polymer | 65.4 | 7 | Chemie (ZN) | |||
| 50 | SB (c) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 1 | Chemie (IHP) |
Sequence modifications
C: 56 - 954 (UniProt: Q15029)
F: 637 - 758 (UniProt: Q8WUQ7)
M: 18 - 306 (UniProt: Q9NW64)
N: 52 - 357 (UniProt: Q96DI7)
| PDB | External Database | Details |
|---|---|---|
| - | Ser 950 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Ala 654 | Glu 665 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 143 | Thr 144 | conflict |
| Ala 144 | Ser 145 | conflict |
| Ala 145 | Asp 146 | conflict |
| Ala 146 | Met 147 | conflict |
| PDB | External Database | Details |
|---|---|---|
| - | Ala 57 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 54 |
| Total formula weight | 2319785.7 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2357.5 | |
| All* | Total formula weight | 2322143.2 |
