6QDV

Human post-catalytic P complex spliceosome

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
7	0000166	molecular_function	nucleotide binding
7	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
7	0000398	biological_process	mRNA splicing, via spliceosome
7	0003676	molecular_function	nucleic acid binding
7	0003723	molecular_function	RNA binding
7	0003724	molecular_function	RNA helicase activity
7	0003729	molecular_function	mRNA binding
7	0004386	molecular_function	helicase activity
7	0005515	molecular_function	protein binding
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005681	cellular_component	spliceosomal complex
7	0005730	cellular_component	nucleolus
7	0005737	cellular_component	cytoplasm
7	0005829	cellular_component	cytosol
7	0006364	biological_process	rRNA processing
7	0006397	biological_process	mRNA processing
7	0006406	biological_process	mRNA export from nucleus
7	0006417	biological_process	regulation of translation
7	0008143	molecular_function	poly(A) binding
7	0008306	biological_process	associative learning
7	0008380	biological_process	RNA splicing
7	0010629	biological_process	negative regulation of gene expression
7	0016020	cellular_component	membrane
7	0016607	cellular_component	nuclear speck
7	0016787	molecular_function	hydrolase activity
7	0016887	molecular_function	ATP hydrolysis activity
7	0017148	biological_process	negative regulation of translation
7	0030425	cellular_component	dendrite
7	0035145	cellular_component	exon-exon junction complex
7	0035368	molecular_function	selenocysteine insertion sequence binding
7	0035613	molecular_function	RNA stem-loop binding
7	0035640	biological_process	exploration behavior
7	0043021	molecular_function	ribonucleoprotein complex binding
7	0043025	cellular_component	neuronal cell body
7	0045727	biological_process	positive regulation of translation
7	0048701	biological_process	embryonic cranial skeleton morphogenesis
7	0051028	biological_process	mRNA transport
7	0071006	cellular_component	U2-type catalytic step 1 spliceosome
7	0071013	cellular_component	catalytic step 2 spliceosome
7	0072715	biological_process	cellular response to selenite ion
7	0090394	biological_process	negative regulation of excitatory postsynaptic potential
7	0098794	cellular_component	postsynapse
7	0098978	cellular_component	glutamatergic synapse
7	0099578	biological_process	regulation of translation at postsynapse, modulating synaptic transmission
7	1904570	biological_process	negative regulation of selenocysteine incorporation
7	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
7	1990904	cellular_component	ribonucleoprotein complex
7	2000622	biological_process	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
8	0003676	molecular_function	nucleic acid binding
8	0003723	molecular_function	RNA binding
8	0003729	molecular_function	mRNA binding
8	0005634	cellular_component	nucleus
8	0005737	cellular_component	cytoplasm
8	0006396	biological_process	RNA processing
9	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
9	0000398	biological_process	mRNA splicing, via spliceosome
9	0003723	molecular_function	RNA binding
9	0005515	molecular_function	protein binding
9	0005634	cellular_component	nucleus
9	0005654	cellular_component	nucleoplasm
9	0005681	cellular_component	spliceosomal complex
9	0005829	cellular_component	cytosol
9	0006397	biological_process	mRNA processing
9	0006406	biological_process	mRNA export from nucleus
9	0008380	biological_process	RNA splicing
9	0035145	cellular_component	exon-exon junction complex
9	0043025	cellular_component	neuronal cell body
9	0050684	biological_process	regulation of mRNA processing
9	0051028	biological_process	mRNA transport
9	0071005	cellular_component	U2-type precatalytic spliceosome
9	0071006	cellular_component	U2-type catalytic step 1 spliceosome
9	0071013	cellular_component	catalytic step 2 spliceosome
9	1990501	cellular_component	exon-exon junction subcomplex mago-y14
9	2000622	biological_process	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000375	biological_process	RNA splicing, via transesterification reactions
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0006397	biological_process	mRNA processing
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008380	biological_process	RNA splicing
A	0016020	cellular_component	membrane
A	0016607	cellular_component	nuclear speck
A	0017070	molecular_function	U6 snRNA binding
A	0030532	cellular_component	small nuclear ribonucleoprotein complex
A	0030619	molecular_function	U1 snRNA binding
A	0030620	molecular_function	U2 snRNA binding
A	0030623	molecular_function	U5 snRNA binding
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0070530	molecular_function	K63-linked polyubiquitin modification-dependent protein binding
A	0071005	cellular_component	U2-type precatalytic spliceosome
A	0071006	cellular_component	U2-type catalytic step 1 spliceosome
A	0071007	cellular_component	U2-type catalytic step 2 spliceosome
A	0071013	cellular_component	catalytic step 2 spliceosome
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0097157	molecular_function	pre-mRNA intronic binding
A	0140492	molecular_function	metal-dependent deubiquitinase activity
A	1990904	cellular_component	ribonucleoprotein complex
B	0003676	molecular_function	nucleic acid binding
B	0005524	molecular_function	ATP binding
C	0000166	molecular_function	nucleotide binding
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0003723	molecular_function	RNA binding
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005681	cellular_component	spliceosomal complex
C	0005829	cellular_component	cytosol
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0015030	cellular_component	Cajal body
C	0016020	cellular_component	membrane
C	0016607	cellular_component	nuclear speck
C	0030623	molecular_function	U5 snRNA binding
C	0042220	biological_process	response to cocaine
C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0071005	cellular_component	U2-type precatalytic spliceosome
C	0071007	cellular_component	U2-type catalytic step 2 spliceosome
C	0071013	cellular_component	catalytic step 2 spliceosome
C	0071466	biological_process	cellular response to xenobiotic stimulus
D	0003725	molecular_function	double-stranded RNA binding
H	0000398	biological_process	mRNA splicing, via spliceosome
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005681	cellular_component	spliceosomal complex
H	0005829	cellular_component	cytosol
H	0006397	biological_process	mRNA processing
H	0008380	biological_process	RNA splicing
H	0016607	cellular_component	nuclear speck
H	0048024	biological_process	regulation of mRNA splicing, via spliceosome
H	0071005	cellular_component	U2-type precatalytic spliceosome
H	0071006	cellular_component	U2-type catalytic step 1 spliceosome
H	0071007	cellular_component	U2-type catalytic step 2 spliceosome
H	0071013	cellular_component	catalytic step 2 spliceosome
J	0000398	biological_process	mRNA splicing, via spliceosome
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0005681	cellular_component	spliceosomal complex
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0000785	cellular_component	chromatin
L	0003713	molecular_function	transcription coactivator activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005681	cellular_component	spliceosomal complex
L	0005813	cellular_component	centrosome
L	0006397	biological_process	mRNA processing
L	0008380	biological_process	RNA splicing
L	0015630	cellular_component	microtubule cytoskeleton
L	0016922	molecular_function	nuclear receptor binding
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0071007	cellular_component	U2-type catalytic step 2 spliceosome
M	0003676	molecular_function	nucleic acid binding
M	0003723	molecular_function	RNA binding
M	0046872	molecular_function	metal ion binding
O	0000077	biological_process	DNA damage checkpoint signaling
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0000974	cellular_component	Prp19 complex
O	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
O	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
O	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
O	0003677	molecular_function	DNA binding
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005662	cellular_component	DNA replication factor A complex
O	0005681	cellular_component	spliceosomal complex
O	0005737	cellular_component	cytoplasm
O	0006281	biological_process	DNA repair
O	0006355	biological_process	regulation of DNA-templated transcription
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0006397	biological_process	mRNA processing
O	0006974	biological_process	DNA damage response
O	0008380	biological_process	RNA splicing
O	0016020	cellular_component	membrane
O	0016607	cellular_component	nuclear speck
O	0019904	molecular_function	protein domain specific binding
O	0042802	molecular_function	identical protein binding
O	0045944	biological_process	positive regulation of transcription by RNA polymerase II
O	0071007	cellular_component	U2-type catalytic step 2 spliceosome
O	0071013	cellular_component	catalytic step 2 spliceosome
O	0071987	molecular_function	WD40-repeat domain binding
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0000974	cellular_component	Prp19 complex
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005681	cellular_component	spliceosomal complex
P	0005739	cellular_component	mitochondrion
P	0006397	biological_process	mRNA processing
P	0008380	biological_process	RNA splicing
P	0016607	cellular_component	nuclear speck
P	0045292	biological_process	mRNA cis splicing, via spliceosome
P	0071007	cellular_component	U2-type catalytic step 2 spliceosome
P	0071013	cellular_component	catalytic step 2 spliceosome
S	0000245	biological_process	spliceosomal complex assembly
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0000974	cellular_component	Prp19 complex
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005681	cellular_component	spliceosomal complex
S	0006396	biological_process	RNA processing
S	0006397	biological_process	mRNA processing
S	0008380	biological_process	RNA splicing
S	0016607	cellular_component	nuclear speck
S	0071007	cellular_component	U2-type catalytic step 2 spliceosome
S	0071013	cellular_component	catalytic step 2 spliceosome
S	0071014	cellular_component	post-mRNA release spliceosomal complex
T	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
T	0000398	biological_process	mRNA splicing, via spliceosome
T	0000974	cellular_component	Prp19 complex
T	0001824	biological_process	blastocyst development
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005681	cellular_component	spliceosomal complex
T	0006281	biological_process	DNA repair
T	0006283	biological_process	transcription-coupled nucleotide-excision repair
T	0006351	biological_process	DNA-templated transcription
T	0006396	biological_process	RNA processing
T	0006397	biological_process	mRNA processing
T	0006974	biological_process	DNA damage response
T	0008380	biological_process	RNA splicing
T	0016020	cellular_component	membrane
T	0021987	biological_process	cerebral cortex development
T	0071007	cellular_component	U2-type catalytic step 2 spliceosome
T	0071013	cellular_component	catalytic step 2 spliceosome
T	0071014	cellular_component	post-mRNA release spliceosomal complex
U	0000166	molecular_function	nucleotide binding
U	0000398	biological_process	mRNA splicing, via spliceosome
U	0003723	molecular_function	RNA binding
U	0003724	molecular_function	RNA helicase activity
U	0003727	molecular_function	single-stranded RNA binding
U	0003729	molecular_function	mRNA binding
U	0004386	molecular_function	helicase activity
U	0005515	molecular_function	protein binding
U	0005524	molecular_function	ATP binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005681	cellular_component	spliceosomal complex
U	0006397	biological_process	mRNA processing
U	0008380	biological_process	RNA splicing
U	0016020	cellular_component	membrane
U	0016787	molecular_function	hydrolase activity
U	0016887	molecular_function	ATP hydrolysis activity
U	0034458	molecular_function	3'-5' RNA helicase activity
U	0071007	cellular_component	U2-type catalytic step 2 spliceosome
U	0071013	cellular_component	catalytic step 2 spliceosome
V	0000166	molecular_function	nucleotide binding
V	0000398	biological_process	mRNA splicing, via spliceosome
V	0003676	molecular_function	nucleic acid binding
V	0003723	molecular_function	RNA binding
V	0003724	molecular_function	RNA helicase activity
V	0004386	molecular_function	helicase activity
V	0005515	molecular_function	protein binding
V	0005524	molecular_function	ATP binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005681	cellular_component	spliceosomal complex
V	0005829	cellular_component	cytosol
V	0006396	biological_process	RNA processing
V	0006397	biological_process	mRNA processing
V	0008186	molecular_function	ATP-dependent activity, acting on RNA
V	0008380	biological_process	RNA splicing
V	0016604	cellular_component	nuclear body
V	0016787	molecular_function	hydrolase activity
V	0016887	molecular_function	ATP hydrolysis activity
V	0042802	molecular_function	identical protein binding
V	0071007	cellular_component	U2-type catalytic step 2 spliceosome
V	0071013	cellular_component	catalytic step 2 spliceosome
V	1990904	cellular_component	ribonucleoprotein complex
W	0000398	biological_process	mRNA splicing, via spliceosome
W	0030620	molecular_function	U2 snRNA binding
Y	0003676	molecular_function	nucleic acid binding
Y	0003723	molecular_function	RNA binding
Z	0003682	molecular_function	chromatin binding
b	0003723	molecular_function	RNA binding
c	0000375	biological_process	RNA splicing, via transesterification reactions
c	0000380	biological_process	alternative mRNA splicing, via spliceosome
c	0000386	molecular_function	second spliceosomal transesterification activity
c	0000389	biological_process	mRNA 3'-splice site recognition
c	0000398	biological_process	mRNA splicing, via spliceosome
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005681	cellular_component	spliceosomal complex
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0006397	biological_process	mRNA processing
c	0006886	biological_process	intracellular protein transport
c	0008270	molecular_function	zinc ion binding
c	0008380	biological_process	RNA splicing
c	0016020	cellular_component	membrane
c	0016607	cellular_component	nuclear speck
c	0030532	cellular_component	small nuclear ribonucleoprotein complex
c	0030628	molecular_function	pre-mRNA 3'-splice site binding
c	0034605	biological_process	cellular response to heat
c	0046872	molecular_function	metal ion binding
c	0071013	cellular_component	catalytic step 2 spliceosome
d	0000387	biological_process	spliceosomal snRNP assembly
d	0003723	molecular_function	RNA binding
d	0005681	cellular_component	spliceosomal complex
d	0006396	biological_process	RNA processing
e	0000398	biological_process	mRNA splicing, via spliceosome
e	0003723	molecular_function	RNA binding
e	0005681	cellular_component	spliceosomal complex
f	0000398	biological_process	mRNA splicing, via spliceosome
f	0003723	molecular_function	RNA binding
f	0005681	cellular_component	spliceosomal complex
g	0000245	biological_process	spliceosomal complex assembly
g	0000387	biological_process	spliceosomal snRNP assembly
g	0000398	biological_process	mRNA splicing, via spliceosome
g	0003723	molecular_function	RNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005681	cellular_component	spliceosomal complex
g	0005682	cellular_component	U5 snRNP
g	0005683	cellular_component	U7 snRNP
g	0005684	cellular_component	U2-type spliceosomal complex
g	0005685	cellular_component	U1 snRNP
g	0005686	cellular_component	U2 snRNP
g	0005687	cellular_component	U4 snRNP
g	0005689	cellular_component	U12-type spliceosomal complex
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0006397	biological_process	mRNA processing
g	0008380	biological_process	RNA splicing
g	0030532	cellular_component	small nuclear ribonucleoprotein complex
g	0034709	cellular_component	methylosome
g	0034719	cellular_component	SMN-Sm protein complex
g	0036261	biological_process	7-methylguanosine cap hypermethylation
g	0043186	cellular_component	P granule
g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
g	0071004	cellular_component	U2-type prespliceosome
g	0071005	cellular_component	U2-type precatalytic spliceosome
g	0071007	cellular_component	U2-type catalytic step 2 spliceosome
g	0071011	cellular_component	precatalytic spliceosome
g	0071013	cellular_component	catalytic step 2 spliceosome
g	0097526	cellular_component	spliceosomal tri-snRNP complex
g	1903241	biological_process	U2-type prespliceosome assembly
g	1990904	cellular_component	ribonucleoprotein complex
h	0000387	biological_process	spliceosomal snRNP assembly
h	0003723	molecular_function	RNA binding
h	0006396	biological_process	RNA processing
i	0000398	biological_process	mRNA splicing, via spliceosome
i	0000413	biological_process	protein peptidyl-prolyl isomerization
i	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005681	cellular_component	spliceosomal complex
i	0006397	biological_process	mRNA processing
i	0006457	biological_process	protein folding
i	0008380	biological_process	RNA splicing
i	0016853	molecular_function	isomerase activity
i	0071007	cellular_component	U2-type catalytic step 2 spliceosome
i	0071013	cellular_component	catalytic step 2 spliceosome
i	0097718	molecular_function	disordered domain specific binding
i	1990403	biological_process	embryonic brain development
j	0000245	biological_process	spliceosomal complex assembly
j	0000387	biological_process	spliceosomal snRNP assembly
j	0000398	biological_process	mRNA splicing, via spliceosome
j	0003723	molecular_function	RNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005681	cellular_component	spliceosomal complex
j	0005682	cellular_component	U5 snRNP
j	0005684	cellular_component	U2-type spliceosomal complex
j	0005685	cellular_component	U1 snRNP
j	0005686	cellular_component	U2 snRNP
j	0005687	cellular_component	U4 snRNP
j	0005689	cellular_component	U12-type spliceosomal complex
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0006397	biological_process	mRNA processing
j	0008380	biological_process	RNA splicing
j	0030532	cellular_component	small nuclear ribonucleoprotein complex
j	0034709	cellular_component	methylosome
j	0034715	cellular_component	pICln-Sm protein complex
j	0034719	cellular_component	SMN-Sm protein complex
j	0036261	biological_process	7-methylguanosine cap hypermethylation
j	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
j	0070062	cellular_component	extracellular exosome
j	0071005	cellular_component	U2-type precatalytic spliceosome
j	0071007	cellular_component	U2-type catalytic step 2 spliceosome
j	0071011	cellular_component	precatalytic spliceosome
j	0071013	cellular_component	catalytic step 2 spliceosome
j	0097525	cellular_component	spliceosomal snRNP complex
j	1903241	biological_process	U2-type prespliceosome assembly
j	1990904	cellular_component	ribonucleoprotein complex
k	0003723	molecular_function	RNA binding
l	0000387	biological_process	spliceosomal snRNP assembly
l	0003723	molecular_function	RNA binding
l	0006396	biological_process	RNA processing
m	0000245	biological_process	spliceosomal complex assembly
m	0000387	biological_process	spliceosomal snRNP assembly
m	0000398	biological_process	mRNA splicing, via spliceosome
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005681	cellular_component	spliceosomal complex
m	0005682	cellular_component	U5 snRNP
m	0005684	cellular_component	U2-type spliceosomal complex
m	0005685	cellular_component	U1 snRNP
m	0005686	cellular_component	U2 snRNP
m	0005687	cellular_component	U4 snRNP
m	0005689	cellular_component	U12-type spliceosomal complex
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0006397	biological_process	mRNA processing
m	0008380	biological_process	RNA splicing
m	0030532	cellular_component	small nuclear ribonucleoprotein complex
m	0034709	cellular_component	methylosome
m	0034715	cellular_component	pICln-Sm protein complex
m	0034719	cellular_component	SMN-Sm protein complex
m	0036261	biological_process	7-methylguanosine cap hypermethylation
m	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
m	0070062	cellular_component	extracellular exosome
m	0071005	cellular_component	U2-type precatalytic spliceosome
m	0071007	cellular_component	U2-type catalytic step 2 spliceosome
m	0071011	cellular_component	precatalytic spliceosome
m	0071013	cellular_component	catalytic step 2 spliceosome
m	0097525	cellular_component	spliceosomal snRNP complex
m	1903241	biological_process	U2-type prespliceosome assembly
m	1990904	cellular_component	ribonucleoprotein complex
n	0000387	biological_process	spliceosomal snRNP assembly
n	0003723	molecular_function	RNA binding
n	0005681	cellular_component	spliceosomal complex
n	0006396	biological_process	RNA processing
o	0000398	biological_process	mRNA splicing, via spliceosome
o	0071013	cellular_component	catalytic step 2 spliceosome
p	0000398	biological_process	mRNA splicing, via spliceosome
p	0003723	molecular_function	RNA binding
p	0005681	cellular_component	spliceosomal complex
q	0000398	biological_process	mRNA splicing, via spliceosome
q	0003723	molecular_function	RNA binding
q	0005681	cellular_component	spliceosomal complex
r	0000245	biological_process	spliceosomal complex assembly
r	0000387	biological_process	spliceosomal snRNP assembly
r	0000398	biological_process	mRNA splicing, via spliceosome
r	0003723	molecular_function	RNA binding
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0005681	cellular_component	spliceosomal complex
r	0005682	cellular_component	U5 snRNP
r	0005683	cellular_component	U7 snRNP
r	0005684	cellular_component	U2-type spliceosomal complex
r	0005685	cellular_component	U1 snRNP
r	0005686	cellular_component	U2 snRNP
r	0005687	cellular_component	U4 snRNP
r	0005689	cellular_component	U12-type spliceosomal complex
r	0005737	cellular_component	cytoplasm
r	0005829	cellular_component	cytosol
r	0006397	biological_process	mRNA processing
r	0008380	biological_process	RNA splicing
r	0030532	cellular_component	small nuclear ribonucleoprotein complex
r	0034709	cellular_component	methylosome
r	0034719	cellular_component	SMN-Sm protein complex
r	0036261	biological_process	7-methylguanosine cap hypermethylation
r	0043186	cellular_component	P granule
r	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
r	0071004	cellular_component	U2-type prespliceosome
r	0071005	cellular_component	U2-type precatalytic spliceosome
r	0071007	cellular_component	U2-type catalytic step 2 spliceosome
r	0071011	cellular_component	precatalytic spliceosome
r	0071013	cellular_component	catalytic step 2 spliceosome
r	0097526	cellular_component	spliceosomal tri-snRNP complex
r	1903241	biological_process	U2-type prespliceosome assembly
r	1990904	cellular_component	ribonucleoprotein complex
s	0000375	biological_process	RNA splicing, via transesterification reactions
s	0000380	biological_process	alternative mRNA splicing, via spliceosome
s	0000398	biological_process	mRNA splicing, via spliceosome
s	0000974	cellular_component	Prp19 complex
s	0001541	biological_process	ovarian follicle development
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0005662	cellular_component	DNA replication factor A complex
s	0005681	cellular_component	spliceosomal complex
s	0005730	cellular_component	nucleolus
s	0005813	cellular_component	centrosome
s	0006397	biological_process	mRNA processing
s	0008380	biological_process	RNA splicing
s	0016607	cellular_component	nuclear speck
s	0030163	biological_process	protein catabolic process
s	0048477	biological_process	oogenesis
s	0048599	biological_process	oocyte development
s	0051225	biological_process	spindle assembly
s	0071007	cellular_component	U2-type catalytic step 2 spliceosome
s	0071013	cellular_component	catalytic step 2 spliceosome
t	0000077	biological_process	DNA damage checkpoint signaling
t	0000209	biological_process	protein polyubiquitination
t	0000244	biological_process	spliceosomal tri-snRNP complex assembly
t	0000245	biological_process	spliceosomal complex assembly
t	0000398	biological_process	mRNA splicing, via spliceosome
t	0000974	cellular_component	Prp19 complex
t	0001833	biological_process	inner cell mass cell proliferation
t	0004842	molecular_function	ubiquitin-protein transferase activity
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005662	cellular_component	DNA replication factor A complex
t	0005681	cellular_component	spliceosomal complex
t	0005737	cellular_component	cytoplasm
t	0005811	cellular_component	lipid droplet
t	0005819	cellular_component	spindle
t	0005856	cellular_component	cytoskeleton
t	0006281	biological_process	DNA repair
t	0006303	biological_process	double-strand break repair via nonhomologous end joining
t	0006397	biological_process	mRNA processing
t	0006974	biological_process	DNA damage response
t	0008104	biological_process	protein localization
t	0008380	biological_process	RNA splicing
t	0008610	biological_process	lipid biosynthetic process
t	0010498	biological_process	proteasomal protein catabolic process
t	0016020	cellular_component	membrane
t	0016567	biological_process	protein ubiquitination
t	0016607	cellular_component	nuclear speck
t	0016740	molecular_function	transferase activity
t	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
t	0035861	cellular_component	site of double-strand break
t	0042802	molecular_function	identical protein binding
t	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
t	0061630	molecular_function	ubiquitin protein ligase activity
t	0070534	biological_process	protein K63-linked ubiquitination
t	0071006	cellular_component	U2-type catalytic step 1 spliceosome
t	0071007	cellular_component	U2-type catalytic step 2 spliceosome
t	0071013	cellular_component	catalytic step 2 spliceosome
u	0000077	biological_process	DNA damage checkpoint signaling
u	0000209	biological_process	protein polyubiquitination
u	0000244	biological_process	spliceosomal tri-snRNP complex assembly
u	0000245	biological_process	spliceosomal complex assembly
u	0000398	biological_process	mRNA splicing, via spliceosome
u	0000974	cellular_component	Prp19 complex
u	0001833	biological_process	inner cell mass cell proliferation
u	0004842	molecular_function	ubiquitin-protein transferase activity
u	0005515	molecular_function	protein binding
u	0005634	cellular_component	nucleus
u	0005654	cellular_component	nucleoplasm
u	0005662	cellular_component	DNA replication factor A complex
u	0005681	cellular_component	spliceosomal complex
u	0005737	cellular_component	cytoplasm
u	0005811	cellular_component	lipid droplet
u	0005819	cellular_component	spindle
u	0005856	cellular_component	cytoskeleton
u	0006281	biological_process	DNA repair
u	0006303	biological_process	double-strand break repair via nonhomologous end joining
u	0006397	biological_process	mRNA processing
u	0006974	biological_process	DNA damage response
u	0008104	biological_process	protein localization
u	0008380	biological_process	RNA splicing
u	0008610	biological_process	lipid biosynthetic process
u	0010498	biological_process	proteasomal protein catabolic process
u	0016020	cellular_component	membrane
u	0016567	biological_process	protein ubiquitination
u	0016607	cellular_component	nuclear speck
u	0016740	molecular_function	transferase activity
u	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
u	0035861	cellular_component	site of double-strand break
u	0042802	molecular_function	identical protein binding
u	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
u	0061630	molecular_function	ubiquitin protein ligase activity
u	0070534	biological_process	protein K63-linked ubiquitination
u	0071006	cellular_component	U2-type catalytic step 1 spliceosome
u	0071007	cellular_component	U2-type catalytic step 2 spliceosome
u	0071013	cellular_component	catalytic step 2 spliceosome
v	0000077	biological_process	DNA damage checkpoint signaling
v	0000209	biological_process	protein polyubiquitination
v	0000244	biological_process	spliceosomal tri-snRNP complex assembly
v	0000245	biological_process	spliceosomal complex assembly
v	0000398	biological_process	mRNA splicing, via spliceosome
v	0000974	cellular_component	Prp19 complex
v	0001833	biological_process	inner cell mass cell proliferation
v	0004842	molecular_function	ubiquitin-protein transferase activity
v	0005515	molecular_function	protein binding
v	0005634	cellular_component	nucleus
v	0005654	cellular_component	nucleoplasm
v	0005662	cellular_component	DNA replication factor A complex
v	0005681	cellular_component	spliceosomal complex
v	0005737	cellular_component	cytoplasm
v	0005811	cellular_component	lipid droplet
v	0005819	cellular_component	spindle
v	0005856	cellular_component	cytoskeleton
v	0006281	biological_process	DNA repair
v	0006303	biological_process	double-strand break repair via nonhomologous end joining
v	0006397	biological_process	mRNA processing
v	0006974	biological_process	DNA damage response
v	0008104	biological_process	protein localization
v	0008380	biological_process	RNA splicing
v	0008610	biological_process	lipid biosynthetic process
v	0010498	biological_process	proteasomal protein catabolic process
v	0016020	cellular_component	membrane
v	0016567	biological_process	protein ubiquitination
v	0016607	cellular_component	nuclear speck
v	0016740	molecular_function	transferase activity
v	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
v	0035861	cellular_component	site of double-strand break
v	0042802	molecular_function	identical protein binding
v	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
v	0061630	molecular_function	ubiquitin protein ligase activity
v	0070534	biological_process	protein K63-linked ubiquitination
v	0071006	cellular_component	U2-type catalytic step 1 spliceosome
v	0071007	cellular_component	U2-type catalytic step 2 spliceosome
v	0071013	cellular_component	catalytic step 2 spliceosome
w	0000077	biological_process	DNA damage checkpoint signaling
w	0000209	biological_process	protein polyubiquitination
w	0000244	biological_process	spliceosomal tri-snRNP complex assembly
w	0000245	biological_process	spliceosomal complex assembly
w	0000398	biological_process	mRNA splicing, via spliceosome
w	0000974	cellular_component	Prp19 complex
w	0001833	biological_process	inner cell mass cell proliferation
w	0004842	molecular_function	ubiquitin-protein transferase activity
w	0005515	molecular_function	protein binding
w	0005634	cellular_component	nucleus
w	0005654	cellular_component	nucleoplasm
w	0005662	cellular_component	DNA replication factor A complex
w	0005681	cellular_component	spliceosomal complex
w	0005737	cellular_component	cytoplasm
w	0005811	cellular_component	lipid droplet
w	0005819	cellular_component	spindle
w	0005856	cellular_component	cytoskeleton
w	0006281	biological_process	DNA repair
w	0006303	biological_process	double-strand break repair via nonhomologous end joining
w	0006397	biological_process	mRNA processing
w	0006974	biological_process	DNA damage response
w	0008104	biological_process	protein localization
w	0008380	biological_process	RNA splicing
w	0008610	biological_process	lipid biosynthetic process
w	0010498	biological_process	proteasomal protein catabolic process
w	0016020	cellular_component	membrane
w	0016567	biological_process	protein ubiquitination
w	0016607	cellular_component	nuclear speck
w	0016740	molecular_function	transferase activity
w	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
w	0035861	cellular_component	site of double-strand break
w	0042802	molecular_function	identical protein binding
w	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
w	0061630	molecular_function	ubiquitin protein ligase activity
w	0070534	biological_process	protein K63-linked ubiquitination
w	0071006	cellular_component	U2-type catalytic step 1 spliceosome
w	0071007	cellular_component	U2-type catalytic step 2 spliceosome
w	0071013	cellular_component	catalytic step 2 spliceosome

Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADEmL

Chain	Residue	Details
7	VAL185-LEU193

---

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YngTkFHRIIkdFMiQGG

Chain	Residue	Details
i	TYR48-GLY65

---

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. VSKGQRVKVKVLSFT

Chain	Residue	Details
V	VAL313-THR327

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSCsmDcKIKLWEV

Chain	Residue	Details
o	LEU304-VAL318
J	LEU303-VAL317
J	ILE345-LEU359
t	LEU407-LEU421
N	LEU81-VAL95
N	LEU124-SER138
N	VAL167-ILE181
N	ILE208-LEU222
N	ILE300-THR314

---

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AiIMLDEAHE

Chain	Residue	Details
V	ALA680-GLU689

---

site_id	PS00997
Number of Residues	23
Details	G10_1 G10 protein signature 1. LCClRCiqtrDtNfgtnCiCRVP

Chain	Residue	Details
L	LEU100-PRO122

---

site_id	PS00998
Number of Residues	10
Details	G10_2 G10 protein signature 2. CtHCGCRGCS

Chain	Residue	Details
L	CYS134-SER143

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N-acetylserine => ECO:0000269|Ref.4, ECO:0000269|Ref.5, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895

Chain	Residue	Details
t	SER2
u	SER2
v	SER2
w	SER2
i	THR119
i	LYS125

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
t	LYS122
t	LYS261
u	LYS122
u	LYS261
v	LYS122
v	LYS261
w	LYS122
w	LYS261

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q99KP6

Chain	Residue	Details
t	LYS179
t	LYS244
u	LYS179
u	LYS244
v	LYS179
v	LYS244
w	LYS179
w	LYS244

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
j	LYS6
j	LYS8
m	LYS6
m	LYS8

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
c	SER235
M	LEU148
M	ASN289

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
c	LYS349
K	LYS115
c	LYS408
K	LYS141
K	LYS158
K	LYS258
K	LYS286

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:18583928, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
O	THR385
7	LYS314
7	LYS382

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
O	THR396
K	LYS193
K	LYS240

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:18583928

Chain	Residue	Details
O	THR404
O	THR411

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
O	THR415
O	THR442

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:18583928, ECO:0007744|PubMed:23186163

Chain	Residue	Details
O	SER417

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:18583928, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
O	THR424
O	THR438

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
O	THR430

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
O	SER437

---

site_id	SWS_FT_FI15
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
O	LYS135
O	LYS487

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
O	LYS219

---