6Q9Y

HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 16 AT 1.20A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Protein Mdm4	polymer	100	11187.0	2	UniProt (O15151)	Homo sapiens (Human)	Double minute 4 protein,Mdm2-like p53-binding protein,Protein Mdmx,p53-binding protein Mdm4
2	C, D (A, B)	7-methoxy-~{N}-[(3~{S})-1-(4-methylphenyl)pyrrolidin-3-yl]-1~{H}-indole-3-carboxamide	non-polymer		349.4	2	Chemie (HRQ)
3	E, F (A, B)	water	water		18.0	177	Chemie (HOH)

Sequence modifications

A, B: 15 - 112 (UniProt: O15151)

PDB	External Database	Details
Gly 13	-	expression tag
Pro 14	-	expression tag
Ser 18	Cys 17	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	22374.0
Non-Polymers*	Number of molecules	2
	Total formula weight	698.9
All*	Total formula weight	23072.8

*Water molecules are not included.