6Q9U
HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 12 AT 2.4A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein Mdm4 | polymer | 100 | 11187.0 | 1 | UniProt (O15151) | Homo sapiens (Human) | Double minute 4 protein,Mdm2-like p53-binding protein,Protein Mdmx,p53-binding protein Mdm4 |
| 2 | B (A) | 4-[(4~{S})-5-(5-chloranyl-2-oxidanylidene-1~{H}-pyridin-3-yl)-2-[2-(dimethylamino)-4-methoxy-pyrimidin-5-yl]-6-oxidanylidene-3-propan-2-yl-4~{H}-pyrrolo[3,4-c]pyrazol-4-yl]benzenecarbonitrile | non-polymer | 545.0 | 1 | Chemie (HRE) | |||
| 3 | C (A) | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE | non-polymer | 264.3 | 1 | Chemie (O4B) | |||
| 4 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | E (A) | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
A: 15 - 112 (UniProt: O15151)
| PDB | External Database | Details |
|---|---|---|
| Gly 13 | - | expression tag |
| Pro 14 | - | expression tag |
| Ser 18 | Cys 17 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 11187.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 844.8 | |
| All* | Total formula weight | 12031.7 |
