6Q9U

HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 12 AT 2.4A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue HRE A 201

Chain	Residue
A	MET54
A	LEU99
A	TYR100
A	HIS55
A	GLY58
A	GLN59
A	ILE61
A	TYR67
A	GLN72
A	VAL93
A	PRO96

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site_id	AC2
Number of Residues	7
Details	binding site for residue O4B A 202

Chain	Residue
A	ILE25
A	VAL28
A	ALA40
A	VAL50
A	VAL63
A	LYS64
A	THR109

---

site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 203

Chain	Residue
A	TYR56
A	GLN59

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	83
Details	Domain: {"description":"SWIB/MDM2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01273","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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