6Q9S
HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 14 AT 2.4A: Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, B | Protein Mdm4 | polymer | 100 | 11187.0 | 3 | UniProt (O15151) In PDB | Homo sapiens (Human) | Double minute 4 protein,Mdm2-like p53-binding protein,Protein Mdmx,p53-binding protein Mdm4 |
| 2 | A, C, B | 3-[[6-chloranyl-3-[3-[(1~{S})-1-(2,4-dichlorophenyl)ethyl]-5-phenyl-imidazol-4-yl]-1~{H}-indol-2-yl]carbonylamino]-4-[4-(2-oxidanylidene-1,3-oxazinan-3-yl)piperidin-1-yl]benzoic acid | non-polymer | 812.1 | 3 | Chemie (HRN) | |||
| 3 | A, C, B | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE | non-polymer | 264.3 | 13 | Chemie (O4B) | |||
| 4 | B, A, C | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 5 | A, C | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 6 | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A, C, B: 15 - 112 (UniProt: O15151)
| PDB | External Database | Details |
|---|---|---|
| Gly 13 | - | expression tag |
| Pro 14 | - | expression tag |
| Ser 18 | Cys 17 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 33561.0 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 6421.8 | |
| All* | Total formula weight | 39982.8 |
