6Q9S

HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 14 AT 2.4A: Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle
B	0005634	cellular_component	nucleus
B	0043066	biological_process	negative regulation of apoptotic process
B	0051726	biological_process	regulation of cell cycle
C	0005634	cellular_component	nucleus
C	0043066	biological_process	negative regulation of apoptotic process
C	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue HRN A 201

Chain	Residue
A	LYS51
A	GLN72
A	VAL93
A	LEU99
A	O4B202
A	O4B204
A	NA206
A	HOH301
A	HOH307
A	MET54
A	HIS55
A	LEU57
A	GLY58
A	ILE61
A	MET62
A	TYR67
A	GLN70

---

site_id	AC2
Number of Residues	3
Details	binding site for residue O4B A 202

Chain	Residue
A	VAL93
A	HRN201
A	NA206

---

site_id	AC3
Number of Residues	7
Details	binding site for residue O4B A 203

Chain	Residue
A	GLN27
A	VAL28
A	VAL50
A	ARG104
A	LEU107
A	THR109
C	GLN24

---

site_id	AC4
Number of Residues	3
Details	binding site for residue O4B A 204

Chain	Residue
A	HIS55
A	GLN59
A	HRN201

---

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 A 205

Chain	Residue
A	GLN44
A	GLY45
A	GLU46
A	MET47

---

site_id	AC6
Number of Residues	2
Details	binding site for residue NA A 206

Chain	Residue
A	HRN201
A	O4B202

---

site_id	AC7
Number of Residues	3
Details	binding site for residue NA A 207

Chain	Residue
A	LYS64
A	GLN65
A	O4B208

---

site_id	AC8
Number of Residues	7
Details	binding site for residue O4B A 208

Chain	Residue
A	GLN65
A	LEU66
A	TYR76
A	NA207
B	VAL93
B	TYR100
B	HRN201

---

site_id	AC9
Number of Residues	11
Details	binding site for residue HRN C 201

Chain	Residue
C	MET54
C	HIS55
C	GLY58
C	ILE61
C	MET62
C	GLN72
C	VAL93
C	PRO96
C	LEU99
C	O4B206
C	O4B207

---

site_id	AD1
Number of Residues	6
Details	binding site for residue O4B C 202

Chain	Residue
B	GLN65
B	GLY79
B	GLU84
C	LEU32
C	PRO33
C	LYS36

---

site_id	AD2
Number of Residues	5
Details	binding site for residue O4B C 203

Chain	Residue
A	GLN24
A	ILE25
C	VAL28
C	VAL50
C	TYR100

---

site_id	AD3
Number of Residues	8
Details	binding site for residue O4B C 204

Chain	Residue
B	ARG29
B	LYS31
B	LYS105
B	LEU110
C	GLY78
C	GLY83
C	GLY87
C	GLN89

---

site_id	AD4
Number of Residues	10
Details	binding site for residue O4B C 205

Chain	Residue
B	GLY78
B	GLU84
B	GLY87
B	ARG88
B	GLN89
C	ARG29
C	LYS31
C	PRO33
C	LYS105
C	ASN106

---

site_id	AD5
Number of Residues	3
Details	binding site for residue O4B C 206

Chain	Residue
C	VAL93
C	HRN201
C	NA211

---

site_id	AD6
Number of Residues	4
Details	binding site for residue O4B C 207

Chain	Residue
C	HIS55
C	GLN59
C	MET62
C	HRN201

---

site_id	AD7
Number of Residues	6
Details	binding site for residue O4B C 208

Chain	Residue
B	LEU85
B	LEU86
B	LYS105
C	GLU84
C	LEU85
C	LYS105

---

site_id	AD8
Number of Residues	4
Details	binding site for residue SO4 C 209

Chain	Residue
C	LYS36
C	TYR60
C	LYS64
C	LEU81

---

site_id	AD9
Number of Residues	4
Details	binding site for residue SO4 C 210

Chain	Residue
B	ARG88
C	GLY45
C	GLU46
C	MET47

---

site_id	AE1
Number of Residues	1
Details	binding site for residue NA C 211

Chain	Residue
C	O4B206

---

site_id	AE2
Number of Residues	15
Details	binding site for residue HRN B 201

Chain	Residue
A	O4B208
B	MET54
B	HIS55
B	LEU57
B	GLY58
B	ILE61
B	MET62
B	TYR67
B	GLN72
B	PHE91
B	VAL93
B	PRO96
B	LEU99
B	TYR100
B	O4B203

---

site_id	AE3
Number of Residues	5
Details	binding site for residue O4B B 202

Chain	Residue
B	LYS36
C	GLN65
C	LEU66
C	ASP68
C	GLY79

---

site_id	AE4
Number of Residues	4
Details	binding site for residue O4B B 203

Chain	Residue
B	HIS55
B	GLN59
B	MET62
B	HRN201

---

site_id	AE5
Number of Residues	5
Details	binding site for residue SO4 B 204

Chain	Residue
B	GLN89
B	GLN89
B	HOH302
C	ARG29
C	ARG29

---

site_id	AE6
Number of Residues	4
Details	binding site for residue SO4 B 205

Chain	Residue
B	GLY45
B	GLU46
B	MET47
C	ARG88

---