6Q9Q
HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 13 AT 2.1A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Protein Mdm4 | polymer | 100 | 11187.0 | 4 | UniProt (O15151) In PDB | Homo sapiens (Human) | Double minute 4 protein,Mdm2-like p53-binding protein,Protein Mdmx,p53-binding protein Mdm4 |
| 2 | A, B, C, D | 6-chloranyl-3-[3-[(1~{S})-1-(4-chlorophenyl)ethyl]-5-phenyl-imidazol-4-yl]-~{N}-[2-(4-cyclohexylpiperazin-1-yl)ethyl]-1~{H}-indole-2-carboxamide | non-polymer | 669.7 | 4 | Chemie (HUE) | |||
| 3 | A, B, C, D | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE | non-polymer | 264.3 | 5 | Chemie (O4B) | |||
| 4 | A, B, C, D | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 5 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | water | water | 18.0 | 150 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 15 - 112 (UniProt: O15151)
| PDB | External Database | Details |
|---|---|---|
| Gly 13 | - | expression tag |
| Pro 14 | - | expression tag |
| Ser 18 | Cys 17 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 44747.9 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 4668.8 | |
| All* | Total formula weight | 49416.7 |
