6Q9Q

HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 13 AT 2.1A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle
B	0005634	cellular_component	nucleus
B	0043066	biological_process	negative regulation of apoptotic process
B	0051726	biological_process	regulation of cell cycle
C	0005634	cellular_component	nucleus
C	0043066	biological_process	negative regulation of apoptotic process
C	0051726	biological_process	regulation of cell cycle
D	0005634	cellular_component	nucleus
D	0043066	biological_process	negative regulation of apoptotic process
D	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue HUE A 201

Chain	Residue
A	MET54
A	HOH317
A	HOH318
B	HIS55
A	GLY58
A	ILE61
A	MET62
A	TYR67
A	GLN72
A	VAL93
A	PRO96
A	LEU99

---

site_id	AC2
Number of Residues	5
Details	binding site for residue O4B A 202

Chain	Residue
A	LYS36
A	LEU81
B	GLN65
B	LEU66
B	TYR76

---

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 A 203

Chain	Residue
A	ILE37
A	ALA40
A	TYR60
A	LYS64
A	HOH309
A	HOH325

---

site_id	AC4
Number of Residues	14
Details	binding site for residue HUE B 201

Chain	Residue
B	MET54
B	LEU57
B	GLY58
B	ILE61
B	MET62
B	GLN72
B	PHE91
B	VAL93
B	PRO96
B	LEU99
B	HOH301
B	HOH326
C	SER97
C	TYR100

---

site_id	AC5
Number of Residues	4
Details	binding site for residue O4B B 202

Chain	Residue
B	LYS36
D	GLN65
D	LEU66
D	TYR76

---

site_id	AC6
Number of Residues	6
Details	binding site for residue O4B B 203

Chain	Residue
B	HIS39
B	GLY42
B	GLN44
B	HOH320
D	GLU71
D	MET74

---

site_id	AC7
Number of Residues	4
Details	binding site for residue SO4 B 204

Chain	Residue
B	THR49
B	VAL50
B	LYS51
C	ARG104

---

site_id	AC8
Number of Residues	5
Details	binding site for residue GOL B 205

Chain	Residue
A	HOH312
B	GLY45
B	GLU46
B	MET47
D	ARG88

---

site_id	AC9
Number of Residues	11
Details	binding site for residue HUE C 201

Chain	Residue
B	LYS94
C	MET54
C	GLY58
C	ILE61
C	TYR67
C	GLN72
C	VAL93
C	PRO96
C	LEU99
C	TYR100
C	HOH315

---

site_id	AD1
Number of Residues	4
Details	binding site for residue O4B C 202

Chain	Residue
A	GLN65
A	LEU66
A	TYR76
C	LYS36

---

site_id	AD2
Number of Residues	4
Details	binding site for residue SO4 C 203

Chain	Residue
A	ARG88
C	GLY45
C	GLU46
C	MET47

---

site_id	AD3
Number of Residues	12
Details	binding site for residue HUE D 201

Chain	Residue
D	ALA41
D	MET54
D	GLY58
D	ILE61
D	MET62
D	TYR67
D	GLN72
D	VAL93
D	PRO96
D	LEU99
D	SO4203
D	HOH310

---

site_id	AD4
Number of Residues	5
Details	binding site for residue O4B D 202

Chain	Residue
C	GLN65
C	LEU66
D	LEU32
D	LYS36
D	LEU81

---

site_id	AD5
Number of Residues	4
Details	binding site for residue SO4 D 203

Chain	Residue
D	HIS55
D	TYR56
D	GLN59
D	HUE201

---

site_id	AD6
Number of Residues	5
Details	binding site for residue SO4 D 204

Chain	Residue
D	TYR60
D	LYS64
D	LYS36
D	ILE37
D	ALA40

---

site_id	AD7
Number of Residues	4
Details	binding site for residue SO4 D 205

Chain	Residue
D	GLY45
D	GLU46
D	MET47
D	HOH303

---