6Q94
Crystal structure of human GDP-D-mannose 4,6-dehydratase (S156D) in complex with GDP-Man
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (B, A, C, D, E...) | GDP-mannose 4,6 dehydratase | polymer | 352 | 40084.5 | 8 | UniProt (O60547) Pfam (PF16363) | Homo sapiens (Human) | GDP-D-mannose dehydratase,GMD |
| 2 | I, K, M, O, S... (B, A, C, D, E...) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 8 | Chemie (NAP) | |||
| 3 | AA, J, L, N, P... (H, B, A, C, D...) | GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE | non-polymer | 605.3 | 8 | Chemie (GDD) | |||
| 4 | BA, Q, R, Y (H, D, G) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 5 | CA, DA, EA, FA (B, C, E, G) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
B, A, C, D, E, F, G, H: 23 - 372 (UniProt: O60547)
| PDB | External Database | Details |
|---|---|---|
| Ser 21 | - | expression tag |
| Met 22 | - | expression tag |
| Asp 156 | Ser 156 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 320675.8 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 11038.2 | |
| All* | Total formula weight | 331714.0 |
