6Q6O
RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 2 AT 2.3A: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nuclear receptor ROR-gamma | polymer | 238 | 27629.9 | 1 | UniProt (P51449) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | B (A) | propan-2-yl (2~{S})-2-[[2,6-bis(chloranyl)phenyl]-(furan-2-ylcarbonyl)amino]propanoate | non-polymer | 370.2 | 1 | Chemie (HKE) | |||
| 3 | C, D (A) | CHOLIC ACID | non-polymer | 408.6 | 2 | Chemie (CHD) | |||
| 4 | E (A) | water | water | 18.0 | 91 | Chemie (HOH) |
Sequence modifications
A: 263 - 499 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Gly 262 | - | expression tag |
| Ser 455 | Cys 455 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27629.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1187.4 | |
| All* | Total formula weight | 28817.3 |
