6Q6O

RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 2 AT 2.3A: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue HKE A 501

Chain	Residue
A	CYS320
A	LEU483
A	HIS323
A	LEU324
A	VAL361
A	PHE378
A	PHE388
A	ILE397
A	ILE400
A	HIS479

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site_id	AC2
Number of Residues	5
Details	binding site for residue CHD A 502

Chain	Residue
A	GLN329
A	GLU333
A	LYS336
A	LYS354
A	CHD503

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site_id	AC3
Number of Residues	5
Details	binding site for residue CHD A 503

Chain	Residue
A	THR325
A	LEU483
A	GLN484
A	GLN487
A	CHD502

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