6Q6M
RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 1: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Nuclear receptor ROR-gamma | polymer | 238 | 27629.9 | 1 | UniProt (P51449) Pfam (PF00104) In PDB | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | A | ethyl (2~{S})-2-[(2-chloranyl-6-methyl-phenyl)-thiophen-2-ylcarbonyl-amino]propanoate | non-polymer | 351.8 | 1 | Chemie (HJW) | |||
| 3 | water | water | 18.0 | 57 | Chemie (HOH) |
Sequence modifications
A: 263 - 499 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Gly 262 | - | expression tag |
| Ser 455 | Cys 455 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27629.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 351.8 | |
| All* | Total formula weight | 27981.8 |
