6Q6G
Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D1 box class
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Cell division cycle protein 20 homolog | polymer | 499 | 54796.5 | 1 | UniProt (Q12834) Pfam (PF12894) Pfam (PF00400) | Homo sapiens (Human) | p55CDC |
| 2 | B (S) | Cyclin-A2 | polymer | 400 | 44944.3 | 1 | UniProt (P20248) Pfam (PF16500) Pfam (PF00134) Pfam (PF02984) | Homo sapiens (Human) | Cyclin-A,Cyclin A |
| 3 | C (L) | Anaphase-promoting complex subunit 10 | polymer | 185 | 21282.1 | 1 | UniProt (Q9UM13) Pfam (PF03256) | Homo sapiens (Human) | APC10,Cyclosome subunit 10 |
| 4 | D (D) | Anaphase-promoting complex subunit 15 | polymer | 121 | 14286.7 | 1 | UniProt (P60006) Pfam (PF15243) | Homo sapiens (Human) | APC15 |
| 5 | E (A) | Anaphase-promoting complex subunit 1,Anaphase-promoting complex subunit 1 | polymer | 1855 | 207282.3 | 1 | UniProt (Q9H1A4) Pfam (PF12859) Pfam (PF20518) Pfam (PF21282) Pfam (PF18122) | Homo sapiens (Human) | APC1,Cyclosome subunit 1,Mitotic checkpoint regulator,Testis-specific gene 24 protein,APC1,Cyclosome subunit 1,Mitotic checkpoint regulator,Testis-specific gene 24 protein |
| 6 | F (N) | Anaphase-promoting complex subunit 2 | polymer | 822 | 93939.0 | 1 | UniProt (Q9UJX6) Pfam (PF00888) Pfam (PF08672) | Homo sapiens (Human) | APC2,Cyclosome subunit 2 |
| 7 | G (I) | Anaphase-promoting complex subunit 4 | polymer | 808 | 92219.2 | 1 | UniProt (Q9UJX5) Pfam (PF12894) Pfam (PF12896) | Homo sapiens (Human) | APC4,Cyclosome subunit 4 |
| 8 | H (O) | Anaphase-promoting complex subunit 5 | polymer | 755 | 85179.8 | 1 | UniProt (Q9UJX4) Pfam (PF21371) Pfam (PF12862) | Homo sapiens (Human) | APC5,Cyclosome subunit 5 |
| 9 | I, Q (K, Q) | Cell division cycle protein 16 homolog | polymer | 620 | 71747.5 | 2 | UniProt (Q13042) Pfam (PF12895) Pfam (PF13424) | Homo sapiens (Human) | Anaphase-promoting complex subunit 6,APC6,CDC16 homolog,CDC16Hs,Cyclosome subunit 6 |
| 10 | J (C) | Anaphase-promoting complex subunit 11 | polymer | 84 | 9854.6 | 1 | UniProt (Q9NYG5) Pfam (PF12861) | Homo sapiens (Human) | APC11,Cyclosome subunit 11,Hepatocellular carcinoma-associated RING finger protein |
| 11 | K, L (G, W) | Anaphase-promoting complex subunit CDC26 | polymer | 85 | 9794.0 | 2 | UniProt (Q8NHZ8) Pfam (PF10471) | Homo sapiens (Human) | Anaphase-promoting complex subunit 12,APC12,Cell division cycle protein 26 homolog |
| 12 | M (M) | Anaphase-promoting complex subunit 13 | polymer | 74 | 8528.3 | 1 | UniProt (Q9BS18) Pfam (PF05839) | Homo sapiens (Human) | APC13,Cyclosome subunit 13 |
| 13 | N (H) | Anaphase-promoting complex subunit 16 | polymer | 110 | 11678.0 | 1 | UniProt (Q96DE5) Pfam (PF17256) | Homo sapiens (Human) | APC16,Cyclosome subunit 16 |
| 14 | O, P (J, P) | Cell division cycle protein 27 homolog | polymer | 824 | 91973.1 | 2 | UniProt (P30260) Pfam (PF12895) Pfam (PF00515) | Homo sapiens (Human) | Anaphase-promoting complex subunit 3,APC3,CDC27 homolog,CDC27Hs,H-NUC |
| 15 | R, U (Y, Z) | Anaphase-promoting complex subunit 7 | polymer | 599 | 66929.4 | 2 | UniProt (Q9UJX3) Pfam (PF13181) Pfam (PF13432) | Homo sapiens (Human) | APC7,Cyclosome subunit 7 |
| 16 | S, T (U, V) | Cell division cycle protein 23 homolog | polymer | 597 | 68921.0 | 2 | UniProt (Q9UJX2) Pfam (PF04049) | Homo sapiens (Human) | Anaphase-promoting complex subunit 8,APC8,Cyclosome subunit 8 |
Sequence modifications
S: 1 - 432 (UniProt: P20248)
A: 1 - 395 (UniProt: Q9H1A4)
A: 397 - 1944 (UniProt: Q9H1A4)
| PDB | External Database | Details |
|---|---|---|
| - | Arg 66 | deletion |
| - | Pro 67 | deletion |
| - | Lys 68 | deletion |
| - | Thr 69 | deletion |
| - | Arg 70 | deletion |
| - | Arg 71 | deletion |
| - | Val 72 | deletion |
| - | Ala 73 | deletion |
| - | Pro 74 | deletion |
| - | Leu 75 | deletion |
| - | Lys 76 | deletion |
| - | Asp 77 | deletion |
| - | Leu 78 | deletion |
| - | Pro 79 | deletion |
| - | Val 80 | deletion |
| - | Asn 81 | deletion |
| - | Asp 82 | deletion |
| - | Glu 83 | deletion |
| - | His 84 | deletion |
| - | Val 85 | deletion |
| - | Thr 86 | deletion |
| - | Val 87 | deletion |
| - | Pro 88 | deletion |
| - | Pro 89 | deletion |
| - | Trp 90 | deletion |
| - | Lys 91 | deletion |
| - | Ala 92 | deletion |
| - | Asn 93 | deletion |
| - | Ser 94 | deletion |
| - | Lys 95 | deletion |
| - | Gln 96 | deletion |
| - | Pro 97 | deletion |
A: 397 - 1944 (UniProt: Q9H1A4)
| PDB | External Database | Details |
|---|---|---|
| Leu 396 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 21 |
| Total formula weight | 1262721.0 | |
| All* | Total formula weight | 1262721.0 |
