6Q5B
OXA-48_P68A-AVI. Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Beta-lactamase | polymer | 265 | 30370.7 | 2 | UniProt (Q6XEC0) Pfam (PF00905) | Klebsiella pneumoniae | |
| 2 | B, D (B, D) | Beta-lactamase | polymer | 265 | 30413.7 | 2 | UniProt (Q6XEC0) Pfam (PF00905) | Klebsiella pneumoniae | |
| 3 | E, I, K, O (A, B, C, D) | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide | non-polymer | 267.3 | 4 | Chemie (NXL) | |||
| 4 | F, L (A, C) | CARBON DIOXIDE | non-polymer | 44.0 | 2 | Chemie (CO2) | |||
| 5 | G, H, J, M (A, B, C) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 6 | N (C) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 699 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 265 (UniProt: Q6XEC0)
B, D: 1 - 265 (UniProt: Q6XEC0)
| PDB | External Database | Details |
|---|---|---|
| Ala 68 | Pro 68 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 68 | Pro 68 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 121568.7 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1394.9 | |
| All* | Total formula weight | 122963.7 |
