6Q5B

OXA-48_P68A-AVI. Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0017001	biological_process	antibiotic catabolic process
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0017001	biological_process	antibiotic catabolic process
C	0008658	molecular_function	penicillin binding
C	0008800	molecular_function	beta-lactamase activity
C	0017001	biological_process	antibiotic catabolic process
D	0008658	molecular_function	penicillin binding
D	0008800	molecular_function	beta-lactamase activity
D	0017001	biological_process	antibiotic catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue NXL A 301

Chain	Residue
A	ALA69
A	HOH485
A	SER70
A	SER118
A	LYS208
A	THR209
A	GLY210
A	TYR211
A	ARG250
A	HOH474

---

site_id	AC2
Number of Residues	1
Details	binding site for residue CO2 A 302

Chain	Residue
A	LYS73

---

site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 303

Chain	Residue
A	ARG206
B	ARG206

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CL A 304

Chain	Residue
A	ASP88
A	GLU89
A	GLN91
A	LEU111

---

site_id	AC5
Number of Residues	11
Details	binding site for residue NXL B 301

Chain	Residue
B	ALA69
B	SER70
B	SER118
B	VAL120
B	LYS208
B	THR209
B	GLY210
B	TYR211
B	ARG250
B	HOH401
B	HOH503

---

site_id	AC6
Number of Residues	3
Details	binding site for residue CL B 302

Chain	Residue
B	SER184
B	ARG186
B	SER187

---

site_id	AC7
Number of Residues	2
Details	binding site for residue CO2 C 302

Chain	Residue
C	SER70
C	LYS73

---

site_id	AC8
Number of Residues	2
Details	binding site for residue CL C 303

Chain	Residue
C	ARG206
D	ARG206

---

site_id	AC9
Number of Residues	7
Details	binding site for residue SO4 C 304

Chain	Residue
C	ASP229
C	ASP230
C	HOH465
D	ASP108
D	HIS109
D	ASN110
D	THR113

---

site_id	AD1
Number of Residues	13
Details	binding site for Di-peptide NXL C 301 and SER C 70

Chain	Residue
C	ALA68
C	ALA69
C	THR71
C	PHE72
C	LYS73
C	SER118
C	LYS208
C	THR209
C	GLY210
C	TYR211
C	ARG250
C	CO2302
C	HOH468

---

site_id	AD2
Number of Residues	13
Details	binding site for Di-peptide NXL D 301 and SER D 70

Chain	Residue
D	ALA68
D	ALA69
D	THR71
D	PHE72
D	KCX73
D	SER118
D	VAL120
D	LYS208
D	THR209
D	GLY210
D	TYR211
D	ARG250
D	HOH402

---

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. AaSTFKIPnSL

Chain	Residue	Details
A	ALA68-LEU78
B	ALA68-LEU78

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26731698","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31358584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32150407","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V1O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8RLA6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P13661","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19477418","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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