6Q54

Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(1-ethyl-4-hydroxy-1H-1,2,3-triazol-5-yl)propanoic acid at 1.4 A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Glutamate receptor 2	polymer	264	29278.7	2	UniProt (P19491) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	A, B	SULFATE ION	non-polymer		96.1	10	Chemie (SO4)
3	A, B	(2~{S})-2-azanyl-3-(3-ethyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic acid	non-polymer		200.2	2	Chemie (HJ8)
4	A, B	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
5	A, B	TRIETHYLENE GLYCOL	non-polymer		150.2	2	Chemie (PGE)
6	A	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
7	A	CITRIC ACID	non-polymer		192.1	1	Chemie (CIT)
8	B, A	LITHIUM ION	non-polymer		6.9	3	Chemie (LI)
9	B	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
10		water	water		18.0	694	Chemie (HOH)

Sequence modifications

A, B: 3 - 117 (UniProt: P19491)

PDB	External Database	Details
Gly 1	-	cloning artifact
Ala 2	-	cloning artifact

A, B: 120 - 264 (UniProt: P19491)

PDB	External Database	Details
Gly 118	-	linker
Thr 119	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58557.5
Non-Polymers*	Number of molecules	26
	Total formula weight	2455.2
All*	Total formula weight	61012.6

*Water molecules are not included.