6Q54
Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(1-ethyl-4-hydroxy-1H-1,2,3-triazol-5-yl)propanoic acid at 1.4 A resolution
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Glutamate receptor 2 | polymer | 264 | 29278.7 | 2 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
2 | A, B | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
3 | A, B | (2~{S})-2-azanyl-3-(3-ethyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic acid | non-polymer | 200.2 | 2 | Chemie (HJ8) | |||
4 | A, B | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
5 | A, B | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
6 | A | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
7 | A | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
8 | B, A | LITHIUM ION | non-polymer | 6.9 | 3 | Chemie (LI) | |||
9 | B | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
10 | water | water | 18.0 | 694 | Chemie (HOH) |
Sequence modifications
A, B: 3 - 117 (UniProt: P19491)
A, B: 120 - 264 (UniProt: P19491)
PDB | External Database | Details |
---|---|---|
Gly 1 | - | cloning artifact |
Ala 2 | - | cloning artifact |
PDB | External Database | Details |
---|---|---|
Gly 118 | - | linker |
Thr 119 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 58557.5 | |
Non-Polymers* | Number of molecules | 26 |
Total formula weight | 2455.2 | |
All* | Total formula weight | 61012.6 |