6Q54

Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(1-ethyl-4-hydroxy-1H-1,2,3-triazol-5-yl)propanoic acid at 1.4 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue SO4 A 301

Chain	Residue
A	ASP139
A	SER140
A	LYS144
A	ARG148
A	HOH408
A	HOH455
A	HOH478
A	HOH535
A	HOH637

---

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 A 302

Chain	Residue
A	SER194
A	GLU198
A	ASN214
A	HOH419
A	HOH578
A	HOH641
A	HOH650

---

site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 A 303

Chain	Residue
A	ARG31
A	HOH407
A	HOH458
A	HOH507
A	HOH542
A	HOH575
B	LYS183

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 304

Chain	Residue
A	LYS45
A	HIS46
A	GLN244
A	HOH401
A	HOH413

---

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 A 305

Chain	Residue
A	LYS21
A	ASN22
A	HIS23
A	GLU24
A	HOH443
A	HOH501

---

site_id	AC6
Number of Residues	6
Details	binding site for residue SO4 A 306

Chain	Residue
A	ARG163
A	SER164
B	LYS21
B	ASN22
B	LEU26
B	HOH405

---

site_id	AC7
Number of Residues	14
Details	binding site for residue HJ8 A 307

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	LEU192
A	GLU193
A	MET196
A	TYR220
A	HOH416
A	HOH475

---

site_id	AC8
Number of Residues	6
Details	binding site for residue GOL A 308

Chain	Residue
A	GLU27
A	GLY28
A	ASN29
A	GLU30
A	HOH554
A	HOH570

---

site_id	AC9
Number of Residues	4
Details	binding site for residue PGE A 309

Chain	Residue
A	LYS144
A	ARG148
A	TRP159
A	ARG163

---

site_id	AD1
Number of Residues	1
Details	binding site for residue CL A 310

Chain	Residue
A	ALA153

---

site_id	AD2
Number of Residues	3
Details	binding site for residue CL A 311

Chain	Residue
A	SER123
A	ALA124
A	HOH659

---

site_id	AD3
Number of Residues	2
Details	binding site for residue CL A 312

Chain	Residue
A	ASN252
A	HOH571

---

site_id	AD4
Number of Residues	11
Details	binding site for residue CIT A 313

Chain	Residue
A	GLU176
A	LYS183
A	HOH486
A	HOH562
A	HOH585
A	HOH591
B	ARG149
B	SER150
B	LYS151
B	ASP156
B	HOH457

---

site_id	AD5
Number of Residues	5
Details	binding site for residue LI A 314

Chain	Residue
A	ALA2
A	THR5
A	HOH467
A	HOH476
A	HOH498

---

site_id	AD6
Number of Residues	4
Details	binding site for residue LI A 315

Chain	Residue
A	GLU97
A	ILE100
A	ASP101
A	HOH437

---

site_id	AD7
Number of Residues	7
Details	binding site for residue SO4 B 301

Chain	Residue
B	SER140
B	LYS144
B	ARG148
B	PEG311
B	HOH411
B	HOH415
B	HOH488

---

site_id	AD8
Number of Residues	4
Details	binding site for residue SO4 B 302

Chain	Residue
B	HOH416
B	HOH479
B	LYS82
B	LYS116

---

site_id	AD9
Number of Residues	2
Details	binding site for residue SO4 B 303

Chain	Residue
B	ARG64
B	LYS69

---

site_id	AE1
Number of Residues	5
Details	binding site for residue SO4 B 304

Chain	Residue
B	SER194
B	GLU198
B	ASN214
B	HOH412
B	HOH428

---

site_id	AE2
Number of Residues	14
Details	binding site for residue HJ8 B 305

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	LEU192
B	GLU193
B	MET196
B	TYR220
B	HOH421
B	HOH523

---

site_id	AE3
Number of Residues	3
Details	binding site for residue GOL B 306

Chain	Residue
B	HIS46
B	LYS240
B	GLN244

---

site_id	AE4
Number of Residues	7
Details	binding site for residue GOL B 307

Chain	Residue
A	ASN3
B	GLY28
B	ARG31
B	LYS52
B	HOH401
B	HOH406
B	HOH673

---

site_id	AE5
Number of Residues	3
Details	binding site for residue GOL B 308

Chain	Residue
B	LYS4
B	THR5
B	HOH458

---

site_id	AE6
Number of Residues	11
Details	binding site for residue PGE B 309

Chain	Residue
A	ASN3
A	LYS258
A	GLU260
A	HOH506
B	MET19
B	HIS23
B	GLU24
B	ARG31
B	HOH404
B	HOH447
B	HOH477

---

site_id	AE7
Number of Residues	4
Details	binding site for residue LI B 310

Chain	Residue
B	GLU97
B	ILE100
B	ASP101
B	HOH453

---

site_id	AE8
Number of Residues	6
Details	binding site for residue PEG B 311

Chain	Residue
B	ARG148
B	TRP159
B	ARG163
B	SO4301
B	HOH422
B	HOH612

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:16483599

Chain	Residue	Details
A	GLU193
B	TYR61
B	ARG96
B	GLU193
A	TYR61
A	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
A	PRO89
B	PRO89

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	SER142
B	THR143
A	THR91
A	SER142
A	THR143
B	THR91

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3

---