6Q4M
Crystal structure of the O-GlcNAc transferase Asn648Tyr mutation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | polymer | 723 | 81023.6 | 1 | UniProt (O15294) Pfam (PF13424) Pfam (PF13414) Pfam (PF13844) In PDB | Homo sapiens (Human) | O-GlcNAc transferase subunit p110,O-linked N-acetylglucosamine transferase 110 kDa subunit |
| 2 | A | (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate | non-polymer | 623.4 | 1 | Chemie (12V) | |||
| 3 | A | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | water | water | 18.0 | 370 | Chemie (HOH) |
Sequence modifications
A: 323 - 1041 (UniProt: O15294)
| PDB | External Database | Details |
|---|---|---|
| Gly 319 | - | expression tag |
| Pro 320 | - | expression tag |
| Gly 321 | - | expression tag |
| Ser 322 | - | expression tag |
| Tyr 648 | Asn 648 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 81023.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 813.4 | |
| All* | Total formula weight | 81836.9 |
