6Q3S
Engineered Human HLA_A2 MHC Class I molecule in complex with TCR and SV9 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 276 | 31923.3 | 1 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) | Homo sapiens (Human) | MHC class I antigen A*2 |
| 2 | B (B) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | C (C) | SER-LEU-LEU-MET-TRP-ILE-THR-GLN-VAL | polymer | 9 | 1090.3 | 1 | Homo sapiens (Human) | ||
| 4 | D (D) | T cell receptor alpha variable 21,T-cell receptor, sp3.4 alpha chain | polymer | 207 | 22571.9 | 1 | UniProt (A0A0B4J279) UniProt (K7N5N2) Pfam (PF07686) Pfam (PF09291) | Homo sapiens (Human) | T-cell receptor,sp3.4 beta chain |
| 5 | E (E) | T cell receptor beta variable 6-5,Human nkt tcr beta chain | polymer | 241 | 27006.0 | 1 | UniProt (A0A0K0K1A5) UniProt (K7N5M4) Pfam (PF07686) Pfam (PF07654) | Homo sapiens (Human) | |
| 6 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | G (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 8 | H, I, J, K (A, B, D, E) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
A: 1 - 276 (UniProt: P01892)
B: 1 - 99 (UniProt: P61769)
D: 2 - 93 (UniProt: A0A0B4J279)
D: 116 - 208 (UniProt: K7N5N2)
E: 2 - 94 (UniProt: A0A0K0K1A5)
E: 116 - 242 (UniProt: K7N5M4)
| PDB | External Database | Details |
|---|---|---|
| Cys 84 | Tyr 108 | conflict |
| Cys 139 | Ala 163 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Pro 94 | - | linker |
| Thr 95 | - | linker |
| Ser 96 | - | linker |
| Gly 97 | - | linker |
| Gly 98 | - | linker |
| Ser 99 | - | linker |
| Tyr 100 | - | linker |
| Ile 101 | - | linker |
| Pro 102 | - | linker |
| Thr 103 | - | linker |
| Phe 104 | - | linker |
| Gly 105 | - | linker |
| Arg 106 | - | linker |
| Gly 107 | - | linker |
| Thr 108 | - | linker |
| Ser 109 | - | linker |
| Leu 110 | - | linker |
| Ile 111 | - | linker |
| Val 112 | - | linker |
| His 113 | - | linker |
| Pro 114 | - | linker |
| Tyr 115 | - | linker |
E: 2 - 94 (UniProt: A0A0K0K1A5)
| PDB | External Database | Details |
|---|---|---|
| Val 95 | - | linker |
| Gly 96 | - | linker |
| Asn 97 | - | linker |
| Thr 98 | - | linker |
| Gly 99 | - | linker |
| Glu 100 | - | linker |
| Leu 101 | - | linker |
| Phe 102 | - | linker |
| Phe 103 | - | linker |
| Gly 104 | - | linker |
| Glu 105 | - | linker |
| Gly 106 | - | linker |
| Ser 107 | - | linker |
| Arg 108 | - | linker |
| Leu 109 | - | linker |
| Thr 110 | - | linker |
| Val 111 | - | linker |
| Leu 112 | - | linker |
| Glu 113 | - | linker |
| Asp 114 | - | linker |
| Leu 115 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Asp 201 | Asn 208 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 94470.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 151.1 | |
| All* | Total formula weight | 94622.0 |
