6Q21

MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	C-H-RAS P21 PROTEIN CATALYTIC DOMAIN	polymer	171	19517.1	4	UniProt (P01112) Pfam (PF00071)	Homo sapiens (human)
2	E, G, I, K (A, B, C, D)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG) PubChem (888)
3	F, H, J, L (A, B, C, D)	PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER	non-polymer		521.2	4	Chemie (GCP)
4	M, N, O, P (A, B, C, D)	water	water		18.0	453	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	78068.2
Non-Polymers*	Number of molecules	8
	Total formula weight	2182.1
All*	Total formula weight	80250.3

*Water molecules are not included.