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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6Q21

MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000165biological_processMAPK cascade
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006357biological_processregulation of transcription by RNA polymerase II
A0006935biological_processchemotaxis
A0007165biological_processsignal transduction
A0007166biological_processcell surface receptor signaling pathway
A0007265biological_processRas protein signal transduction
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0008286biological_processinsulin receptor signaling pathway
A0009887biological_processanimal organ morphogenesis
A0010629biological_processnegative regulation of gene expression
A0014044biological_processSchwann cell development
A0016020cellular_componentmembrane
A0019003molecular_functionGDP binding
A0030335biological_processpositive regulation of cell migration
A0032956biological_processregulation of actin cytoskeleton organization
A0042127biological_processregulation of cell population proliferation
A0042552biological_processmyelination
A0043410biological_processpositive regulation of MAPK cascade
A0043495molecular_functionprotein-membrane adaptor activity
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046330biological_processpositive regulation of JNK cascade
A0046579biological_processpositive regulation of Ras protein signal transduction
A0048471cellular_componentperinuclear region of cytoplasm
A0050679biological_processpositive regulation of epithelial cell proliferation
A0051726biological_processregulation of cell cycle
A0060612biological_processadipose tissue development
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071480biological_processcellular response to gamma radiation
A0090303biological_processpositive regulation of wound healing
A0090314biological_processpositive regulation of protein targeting to membrane
A0090398biological_processcellular senescence
A0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A0098978cellular_componentglutamatergic synapse
A0160185molecular_functionphospholipase C activator activity
A1900029biological_processpositive regulation of ruffle assembly
A2000630biological_processpositive regulation of miRNA metabolic process
B0000139cellular_componentGolgi membrane
B0000165biological_processMAPK cascade
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006357biological_processregulation of transcription by RNA polymerase II
B0006935biological_processchemotaxis
B0007165biological_processsignal transduction
B0007166biological_processcell surface receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008284biological_processpositive regulation of cell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0008286biological_processinsulin receptor signaling pathway
B0009887biological_processanimal organ morphogenesis
B0010629biological_processnegative regulation of gene expression
B0014044biological_processSchwann cell development
B0016020cellular_componentmembrane
B0019003molecular_functionGDP binding
B0030335biological_processpositive regulation of cell migration
B0032956biological_processregulation of actin cytoskeleton organization
B0042127biological_processregulation of cell population proliferation
B0042552biological_processmyelination
B0043410biological_processpositive regulation of MAPK cascade
B0043495molecular_functionprotein-membrane adaptor activity
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046330biological_processpositive regulation of JNK cascade
B0046579biological_processpositive regulation of Ras protein signal transduction
B0048471cellular_componentperinuclear region of cytoplasm
B0050679biological_processpositive regulation of epithelial cell proliferation
B0051726biological_processregulation of cell cycle
B0060612biological_processadipose tissue development
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0071480biological_processcellular response to gamma radiation
B0090303biological_processpositive regulation of wound healing
B0090314biological_processpositive regulation of protein targeting to membrane
B0090398biological_processcellular senescence
B0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
B0098978cellular_componentglutamatergic synapse
B0160185molecular_functionphospholipase C activator activity
B1900029biological_processpositive regulation of ruffle assembly
B2000630biological_processpositive regulation of miRNA metabolic process
C0000139cellular_componentGolgi membrane
C0000165biological_processMAPK cascade
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006357biological_processregulation of transcription by RNA polymerase II
C0006935biological_processchemotaxis
C0007165biological_processsignal transduction
C0007166biological_processcell surface receptor signaling pathway
C0007265biological_processRas protein signal transduction
C0008284biological_processpositive regulation of cell population proliferation
C0008285biological_processnegative regulation of cell population proliferation
C0008286biological_processinsulin receptor signaling pathway
C0009887biological_processanimal organ morphogenesis
C0010629biological_processnegative regulation of gene expression
C0014044biological_processSchwann cell development
C0016020cellular_componentmembrane
C0019003molecular_functionGDP binding
C0030335biological_processpositive regulation of cell migration
C0032956biological_processregulation of actin cytoskeleton organization
C0042127biological_processregulation of cell population proliferation
C0042552biological_processmyelination
C0043410biological_processpositive regulation of MAPK cascade
C0043495molecular_functionprotein-membrane adaptor activity
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046330biological_processpositive regulation of JNK cascade
C0046579biological_processpositive regulation of Ras protein signal transduction
C0048471cellular_componentperinuclear region of cytoplasm
C0050679biological_processpositive regulation of epithelial cell proliferation
C0051726biological_processregulation of cell cycle
C0060612biological_processadipose tissue development
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0071480biological_processcellular response to gamma radiation
C0090303biological_processpositive regulation of wound healing
C0090314biological_processpositive regulation of protein targeting to membrane
C0090398biological_processcellular senescence
C0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
C0098978cellular_componentglutamatergic synapse
C0160185molecular_functionphospholipase C activator activity
C1900029biological_processpositive regulation of ruffle assembly
C2000630biological_processpositive regulation of miRNA metabolic process
D0000139cellular_componentGolgi membrane
D0000165biological_processMAPK cascade
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005789cellular_componentendoplasmic reticulum membrane
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006357biological_processregulation of transcription by RNA polymerase II
D0006935biological_processchemotaxis
D0007165biological_processsignal transduction
D0007166biological_processcell surface receptor signaling pathway
D0007265biological_processRas protein signal transduction
D0008284biological_processpositive regulation of cell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0008286biological_processinsulin receptor signaling pathway
D0009887biological_processanimal organ morphogenesis
D0010629biological_processnegative regulation of gene expression
D0014044biological_processSchwann cell development
D0016020cellular_componentmembrane
D0019003molecular_functionGDP binding
D0030335biological_processpositive regulation of cell migration
D0032956biological_processregulation of actin cytoskeleton organization
D0042127biological_processregulation of cell population proliferation
D0042552biological_processmyelination
D0043410biological_processpositive regulation of MAPK cascade
D0043495molecular_functionprotein-membrane adaptor activity
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046330biological_processpositive regulation of JNK cascade
D0046579biological_processpositive regulation of Ras protein signal transduction
D0048471cellular_componentperinuclear region of cytoplasm
D0050679biological_processpositive regulation of epithelial cell proliferation
D0051726biological_processregulation of cell cycle
D0060612biological_processadipose tissue development
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0071480biological_processcellular response to gamma radiation
D0090303biological_processpositive regulation of wound healing
D0090314biological_processpositive regulation of protein targeting to membrane
D0090398biological_processcellular senescence
D0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
D0098978cellular_componentglutamatergic synapse
D0160185molecular_functionphospholipase C activator activity
D1900029biological_processpositive regulation of ruffle assembly
D2000630biological_processpositive regulation of miRNA metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 173
ChainResidue
ASER17
ATHR35
AGCP180
AHOH800
AHOH801
site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B 173
ChainResidue
BHOH804
BSER17
BTHR35
BGCP180
BHOH803
site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG C 173
ChainResidue
CSER17
CTHR35
CGCP180
CHOH806
CHOH807
site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG D 173
ChainResidue
DSER17
DGCP180
DHOH809
DHOH810
DHOH812
site_idAC5
Number of Residues25
DetailsBINDING SITE FOR RESIDUE GCP A 180
ChainResidue
AGLY12
AGLY13
AVAL14
AGLY15
ALYS16
ASER17
AALA18
APHE28
AASP30
APRO34
ATHR35
AALA59
AGLY60
AGLN61
AASN116
ALYS117
AASP119
ASER145
AALA146
ALYS147
AMG173
AHOH800
AHOH801
AHOH802
AHOH1127
site_idAC6
Number of Residues25
DetailsBINDING SITE FOR RESIDUE GCP B 180
ChainResidue
BGLY12
BGLY13
BVAL14
BGLY15
BLYS16
BSER17
BALA18
BPHE28
BVAL29
BASP30
BTYR32
BPRO34
BTHR35
BGLY60
BASN116
BLYS117
BASP119
BLEU120
BSER145
BALA146
BLYS147
BMG173
BHOH803
BHOH804
BHOH831
site_idAC7
Number of Residues25
DetailsBINDING SITE FOR RESIDUE GCP C 180
ChainResidue
CGLY12
CGLY13
CVAL14
CGLY15
CLYS16
CSER17
CALA18
CPHE28
CVAL29
CASP30
CGLU31
CPRO34
CTHR35
CGLY60
CASN116
CLYS117
CASP119
CLEU120
CALA146
CLYS147
CMG173
CHOH806
CHOH807
CHOH820
CHOH1100
site_idAC8
Number of Residues24
DetailsBINDING SITE FOR RESIDUE GCP D 180
ChainResidue
DSER17
DALA18
DASP30
DASP33
DPRO34
DGLY60
DASN116
DLYS117
DASP119
DLEU120
DSER145
DALA146
DLYS147
DMG173
DHOH810
DHOH812
DHOH813
DHOH872
DHOH1059
DHOH1205
DGLY13
DVAL14
DGLY15
DLYS16
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues32
DetailsMotif: {"description":"Effector region"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues68
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16698776","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"N-acetylmethionine; in GTPase HRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsModified residue: {"description":"N-acetylthreonine; in GTPase HRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsModified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"9020151","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9632667","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"30442762","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLN61
site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
BGLN61
site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
CGLN61
site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
DGLN61

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