6Q0K

Structure of a MAPK pathway complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine/threonine-protein kinase B-raf	polymer	805	89322.8	2	UniProt (P15056) Pfam (PF02196) Pfam (PF00130) Pfam (PF07714)	Homo sapiens (Human)	Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1
2	C, D (X, Y)	14-3-3 protein zeta/delta	polymer	245	27777.1	2	UniProt (P63104) Pfam (PF00244)	Homo sapiens (Human)	Protein kinase C inhibitor protein 1,KCIP-1

Sequence modifications

A, B: 1 - 766 (UniProt: P15056)

PDB	External Database	Details
Met -26	-	expression tag
Ser -25	-	expression tag
Tyr -24	-	expression tag
Tyr -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Asp -14	-	expression tag
Ile -13	-	expression tag
Pro -12	-	expression tag
Thr -11	-	expression tag
Thr -10	-	expression tag
Glu -9	-	expression tag
Asn -8	-	expression tag
Leu -7	-	expression tag
Tyr -6	-	expression tag
Phe -5	-	expression tag
Gln -4	-	expression tag
Gly -3	-	expression tag
Ala -2	-	expression tag
Met -1	-	expression tag
Asp 0	-	expression tag
Gly 767	-	expression tag
Thr 768	-	expression tag
Ser 769	-	expression tag
Ala 770	-	expression tag
Trp 771	-	expression tag
Ser 772	-	expression tag
His 773	-	expression tag
Pro 774	-	expression tag
Gln 775	-	expression tag
Phe 776	-	expression tag
Glu 777	-	expression tag
Lys 778	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	234199.8
All*	Total formula weight	234199.8

*Water molecules are not included.