6Q0K

Structure of a MAPK pathway complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000165	biological_process	MAPK cascade
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004708	molecular_function	MAP kinase kinase activity
A	0004709	molecular_function	MAP kinase kinase kinase activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006468	biological_process	protein phosphorylation
A	0007165	biological_process	signal transduction
A	0007173	biological_process	epidermal growth factor receptor signaling pathway
A	0008270	molecular_function	zinc ion binding
A	0009887	biological_process	animal organ morphogenesis
A	0010628	biological_process	positive regulation of gene expression
A	0010828	biological_process	positive regulation of D-glucose transmembrane transport
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0031267	molecular_function	small GTPase binding
A	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
A	0042802	molecular_function	identical protein binding
A	0043005	cellular_component	neuron projection
A	0043066	biological_process	negative regulation of apoptotic process
A	0044297	cellular_component	cell body
A	0046872	molecular_function	metal ion binding
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0071277	biological_process	cellular response to calcium ion
A	0090150	biological_process	establishment of protein localization to membrane
A	0097110	molecular_function	scaffold protein binding
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
A	0106310	molecular_function	protein serine kinase activity
B	0000165	biological_process	MAPK cascade
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004708	molecular_function	MAP kinase kinase activity
B	0004709	molecular_function	MAP kinase kinase kinase activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006468	biological_process	protein phosphorylation
B	0007165	biological_process	signal transduction
B	0007173	biological_process	epidermal growth factor receptor signaling pathway
B	0008270	molecular_function	zinc ion binding
B	0009887	biological_process	animal organ morphogenesis
B	0010628	biological_process	positive regulation of gene expression
B	0010828	biological_process	positive regulation of D-glucose transmembrane transport
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0031267	molecular_function	small GTPase binding
B	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
B	0042802	molecular_function	identical protein binding
B	0043005	cellular_component	neuron projection
B	0043066	biological_process	negative regulation of apoptotic process
B	0044297	cellular_component	cell body
B	0046872	molecular_function	metal ion binding
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	0071277	biological_process	cellular response to calcium ion
B	0090150	biological_process	establishment of protein localization to membrane
B	0097110	molecular_function	scaffold protein binding
B	0098794	cellular_component	postsynapse
B	0098978	cellular_component	glutamatergic synapse
B	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
B	0106310	molecular_function	protein serine kinase activity
X	0000122	biological_process	negative regulation of transcription by RNA polymerase II
X	0001525	biological_process	angiogenesis
X	0003016	biological_process	respiratory system process
X	0003723	molecular_function	RNA binding
X	0005515	molecular_function	protein binding
X	0005615	cellular_component	extracellular space
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005925	cellular_component	focal adhesion
X	0006468	biological_process	protein phosphorylation
X	0007165	biological_process	signal transduction
X	0008039	biological_process	synaptic target recognition
X	0008104	biological_process	intracellular protein localization
X	0019901	molecular_function	protein kinase binding
X	0019903	molecular_function	protein phosphatase binding
X	0019904	molecular_function	protein domain specific binding
X	0030324	biological_process	lung development
X	0031625	molecular_function	ubiquitin protein ligase binding
X	0031647	biological_process	regulation of protein stability
X	0031982	cellular_component	vesicle
X	0035148	biological_process	tube formation
X	0042149	biological_process	cellular response to glucose starvation
X	0042470	cellular_component	melanosome
X	0042802	molecular_function	identical protein binding
X	0043066	biological_process	negative regulation of apoptotic process
X	0044325	molecular_function	transmembrane transporter binding
X	0045296	molecular_function	cadherin binding
X	0045824	biological_process	negative regulation of innate immune response
X	0050815	molecular_function	phosphoserine residue binding
X	0051683	biological_process	establishment of Golgi localization
X	0070062	cellular_component	extracellular exosome
X	0070372	biological_process	regulation of ERK1 and ERK2 cascade
X	0072562	cellular_component	blood microparticle
X	0090128	biological_process	regulation of synapse maturation
X	0090168	biological_process	Golgi reassembly
X	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
X	0098978	cellular_component	glutamatergic synapse
X	0140297	molecular_function	DNA-binding transcription factor binding
X	0140311	molecular_function	protein sequestering activity
X	1900181	biological_process	negative regulation of protein localization to nucleus
X	1904262	biological_process	negative regulation of TORC1 signaling
Y	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Y	0001525	biological_process	angiogenesis
Y	0003016	biological_process	respiratory system process
Y	0003723	molecular_function	RNA binding
Y	0005515	molecular_function	protein binding
Y	0005615	cellular_component	extracellular space
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0005925	cellular_component	focal adhesion
Y	0006468	biological_process	protein phosphorylation
Y	0007165	biological_process	signal transduction
Y	0008039	biological_process	synaptic target recognition
Y	0008104	biological_process	intracellular protein localization
Y	0019901	molecular_function	protein kinase binding
Y	0019903	molecular_function	protein phosphatase binding
Y	0019904	molecular_function	protein domain specific binding
Y	0030324	biological_process	lung development
Y	0031625	molecular_function	ubiquitin protein ligase binding
Y	0031647	biological_process	regulation of protein stability
Y	0031982	cellular_component	vesicle
Y	0035148	biological_process	tube formation
Y	0042149	biological_process	cellular response to glucose starvation
Y	0042470	cellular_component	melanosome
Y	0042802	molecular_function	identical protein binding
Y	0043066	biological_process	negative regulation of apoptotic process
Y	0044325	molecular_function	transmembrane transporter binding
Y	0045296	molecular_function	cadherin binding
Y	0045824	biological_process	negative regulation of innate immune response
Y	0050815	molecular_function	phosphoserine residue binding
Y	0051683	biological_process	establishment of Golgi localization
Y	0070062	cellular_component	extracellular exosome
Y	0070372	biological_process	regulation of ERK1 and ERK2 cascade
Y	0072562	cellular_component	blood microparticle
Y	0090128	biological_process	regulation of synapse maturation
Y	0090168	biological_process	Golgi reassembly
Y	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
Y	0098978	cellular_component	glutamatergic synapse
Y	0140297	molecular_function	DNA-binding transcription factor binding
Y	0140311	molecular_function	protein sequestering activity
Y	1900181	biological_process	negative regulation of protein localization to nucleus
Y	1904262	biological_process	negative regulation of TORC1 signaling

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	21
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGTVYkGkwhgd.............VAVK

Chain	Residue	Details
A	ILE463-LYS483

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKsnNIFL

Chain	Residue	Details
A	ILE572-LEU584

---

site_id	PS00479
Number of Residues	46
Details	ZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HnFvrktfftlaf.CdfCrklLfqgfr.....CqtCgykfHqrCstevplm..C

Chain	Residue	Details
A	HIS235-CYS280

---

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
X	ARG41-VAL51

---

site_id	PS00797
Number of Residues	20
Details	1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS

Chain	Residue	Details
X	TYR211-SER230

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Omega-N-methylarginine; by PRMT5","evidences":[{"source":"PubMed","id":"21917714","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Boldt K.","von Kriegsheim A.F.","Zebisch A.","Kolch W."]}},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23907581","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Site: {"description":"Interaction with phosphoserine on interacting protein","evidences":[{"source":"UniProtKB","id":"P63103","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKA and PKB/AKT1","evidences":[{"source":"PubMed","id":"11956222","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12865427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15883165","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16376338","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by MAPK8","evidences":[{"source":"PubMed","id":"15071501","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15696159","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P63102","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---