6PYY
Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PF-06840003 in Active Site and Exo site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tryptophan 2,3-dioxygenase | polymer | 380 | 45182.5 | 4 | UniProt (P48775) Pfam (PF03301) | Homo sapiens (Human) | TDO,Tryptamin 2,3-dioxygenase,Tryptophan oxygenase,TRPO,Tryptophan pyrrolase,Tryptophanase |
| 2 | E, H, K, N (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | F, G, I, J, L... (A, B, C, D) | (3S)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione | non-polymer | 232.2 | 8 | Chemie (H7S) | |||
| 4 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 412 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 18 - 389 (UniProt: P48775)
| PDB | External Database | Details |
|---|---|---|
| Met 17 | - | initiating methionine |
| Glu 390 | - | expression tag |
| His 391 | - | expression tag |
| His 392 | - | expression tag |
| His 393 | - | expression tag |
| His 394 | - | expression tag |
| His 395 | - | expression tag |
| His 396 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 180730.1 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4323.6 | |
| All* | Total formula weight | 185053.8 |
