6PYY
Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PF-06840003 in Active Site and Exo site
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004833 | molecular_function | tryptophan 2,3-dioxygenase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005829 | cellular_component | cytosol |
A | 0006568 | biological_process | tryptophan metabolic process |
A | 0006569 | biological_process | tryptophan catabolic process |
A | 0016597 | molecular_function | amino acid binding |
A | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
A | 0019442 | biological_process | tryptophan catabolic process to acetyl-CoA |
A | 0019825 | molecular_function | oxygen binding |
A | 0020037 | molecular_function | heme binding |
A | 0042802 | molecular_function | identical protein binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0051213 | molecular_function | dioxygenase activity |
A | 0051289 | biological_process | protein homotetramerization |
A | 1904842 | biological_process | response to nitroglycerin |
B | 0004833 | molecular_function | tryptophan 2,3-dioxygenase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005829 | cellular_component | cytosol |
B | 0006568 | biological_process | tryptophan metabolic process |
B | 0006569 | biological_process | tryptophan catabolic process |
B | 0016597 | molecular_function | amino acid binding |
B | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
B | 0019442 | biological_process | tryptophan catabolic process to acetyl-CoA |
B | 0019825 | molecular_function | oxygen binding |
B | 0020037 | molecular_function | heme binding |
B | 0042802 | molecular_function | identical protein binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0051213 | molecular_function | dioxygenase activity |
B | 0051289 | biological_process | protein homotetramerization |
B | 1904842 | biological_process | response to nitroglycerin |
C | 0004833 | molecular_function | tryptophan 2,3-dioxygenase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005829 | cellular_component | cytosol |
C | 0006568 | biological_process | tryptophan metabolic process |
C | 0006569 | biological_process | tryptophan catabolic process |
C | 0016597 | molecular_function | amino acid binding |
C | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
C | 0019442 | biological_process | tryptophan catabolic process to acetyl-CoA |
C | 0019825 | molecular_function | oxygen binding |
C | 0020037 | molecular_function | heme binding |
C | 0042802 | molecular_function | identical protein binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0051213 | molecular_function | dioxygenase activity |
C | 0051289 | biological_process | protein homotetramerization |
C | 1904842 | biological_process | response to nitroglycerin |
D | 0004833 | molecular_function | tryptophan 2,3-dioxygenase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005829 | cellular_component | cytosol |
D | 0006568 | biological_process | tryptophan metabolic process |
D | 0006569 | biological_process | tryptophan catabolic process |
D | 0016597 | molecular_function | amino acid binding |
D | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
D | 0019442 | biological_process | tryptophan catabolic process to acetyl-CoA |
D | 0019825 | molecular_function | oxygen binding |
D | 0020037 | molecular_function | heme binding |
D | 0042802 | molecular_function | identical protein binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0051213 | molecular_function | dioxygenase activity |
D | 0051289 | biological_process | protein homotetramerization |
D | 1904842 | biological_process | response to nitroglycerin |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 21 |
Details | binding site for residue HEM A 401 |
Chain | Residue |
A | HIS76 |
A | ARG325 |
A | HIS328 |
A | MET331 |
A | VAL332 |
A | MET335 |
A | GLY341 |
A | GLY343 |
A | SER345 |
A | TYR350 |
A | H7S402 |
A | TYR79 |
A | HOH502 |
A | HOH552 |
A | PHE140 |
A | SER151 |
A | GLY152 |
A | PHE153 |
A | PHE158 |
A | ARG159 |
A | ASN176 |
site_id | AC2 |
Number of Residues | 10 |
Details | binding site for residue H7S A 402 |
Chain | Residue |
A | PHE72 |
A | HIS76 |
A | ARG144 |
A | ALA150 |
A | SER151 |
A | LEU336 |
A | THR342 |
A | HEM401 |
B | TYR42 |
B | TYR45 |
site_id | AC3 |
Number of Residues | 9 |
Details | binding site for residue H7S A 403 |
Chain | Residue |
A | ARG103 |
A | GLU105 |
A | TRP208 |
A | ARG211 |
A | THR212 |
A | PRO213 |
A | ARG303 |
A | PHE304 |
A | HOH533 |
site_id | AC4 |
Number of Residues | 22 |
Details | binding site for residue HEM B 401 |
Chain | Residue |
B | HIS76 |
B | TYR79 |
B | LEU132 |
B | SER151 |
B | GLY152 |
B | PHE153 |
B | PHE158 |
B | ARG159 |
B | ARG325 |
B | HIS328 |
B | MET331 |
B | VAL332 |
B | GLY341 |
B | THR342 |
B | GLY343 |
B | GLY344 |
B | SER345 |
B | GLY347 |
B | TYR350 |
B | H7S402 |
B | HOH503 |
B | HOH538 |
site_id | AC5 |
Number of Residues | 10 |
Details | binding site for residue H7S B 402 |
Chain | Residue |
A | TYR42 |
A | TYR45 |
B | PHE72 |
B | HIS76 |
B | ARG144 |
B | ALA150 |
B | SER151 |
B | LEU336 |
B | THR342 |
B | HEM401 |
site_id | AC6 |
Number of Residues | 11 |
Details | binding site for residue H7S B 403 |
Chain | Residue |
B | VAL102 |
B | ARG103 |
B | GLU105 |
B | TRP208 |
B | ARG211 |
B | THR212 |
B | PRO213 |
B | ARG303 |
B | PHE304 |
B | HOH517 |
B | HOH532 |
site_id | AC7 |
Number of Residues | 21 |
Details | binding site for residue HEM C 401 |
Chain | Residue |
C | TYR350 |
C | THR354 |
C | H7S402 |
C | HOH501 |
D | TYR42 |
C | HIS76 |
C | MET135 |
C | SER151 |
C | GLY152 |
C | PHE153 |
C | PHE158 |
C | ARG159 |
C | TRP324 |
C | HIS328 |
C | MET331 |
C | VAL332 |
C | MET335 |
C | GLY341 |
C | GLY343 |
C | SER345 |
C | GLY347 |
site_id | AC8 |
Number of Residues | 10 |
Details | binding site for residue H7S C 402 |
Chain | Residue |
C | PHE72 |
C | HIS76 |
C | ARG144 |
C | ALA150 |
C | SER151 |
C | LEU336 |
C | THR342 |
C | HEM401 |
D | TYR42 |
D | TYR45 |
site_id | AC9 |
Number of Residues | 8 |
Details | binding site for residue H7S C 403 |
Chain | Residue |
C | ARG103 |
C | GLU105 |
C | TRP208 |
C | ARG211 |
C | THR212 |
C | PRO213 |
C | ARG303 |
C | PHE304 |
site_id | AD1 |
Number of Residues | 19 |
Details | binding site for residue HEM D 401 |
Chain | Residue |
C | TYR42 |
D | PHE72 |
D | HIS76 |
D | TYR79 |
D | SER151 |
D | GLY152 |
D | PHE158 |
D | ARG159 |
D | TYR175 |
D | ARG325 |
D | HIS328 |
D | MET331 |
D | VAL332 |
D | MET335 |
D | TYR350 |
D | THR354 |
D | H7S402 |
D | HOH534 |
D | HOH550 |
site_id | AD2 |
Number of Residues | 7 |
Details | binding site for residue H7S D 402 |
Chain | Residue |
C | TYR42 |
C | TYR45 |
D | PHE72 |
D | HIS76 |
D | ALA150 |
D | SER151 |
D | HEM401 |
site_id | AD3 |
Number of Residues | 7 |
Details | binding site for residue H7S D 403 |
Chain | Residue |
D | ARG103 |
D | TRP208 |
D | ARG211 |
D | THR212 |
D | PRO213 |
D | ARG303 |
D | PHE304 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:27762317, ECO:0007744|PDB:5TI9 |
Chain | Residue | Details |
A | PHE72 | |
D | PHE72 | |
D | ARG144 | |
D | THR342 | |
A | ARG144 | |
A | THR342 | |
B | PHE72 | |
B | ARG144 | |
B | THR342 | |
C | PHE72 | |
C | ARG144 | |
C | THR342 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: axial binding residue => ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:27762317, ECO:0007744|PDB:5TI9 |
Chain | Residue | Details |
A | HIS328 | |
B | HIS328 | |
C | HIS328 | |
D | HIS328 |