6PXF
Structure of human Cathepsin K with an ectosteric inhibitor at 1.85 Angstrom resolution
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cathepsin K | polymer | 215 | 23507.5 | 1 | UniProt (P43235) Pfam (PF00112) In PDB | Homo sapiens (Human) | Cathepsin O,Cathepsin O2,Cathepsin X |
2 | A | 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonic acid | non-polymer | 374.4 | 4 | Chemie (J0V) | |||
3 | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A: 1 - 215 (UniProt: P43235)
PDB | External Database | Details |
---|---|---|
Ala 49 | Ser 163 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 23507.5 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1497.6 | |
All* | Total formula weight | 25005.1 |