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6PXF

Structure of human Cathepsin K with an ectosteric inhibitor at 1.85 Angstrom resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0006508biological_processproteolysis
A0008234molecular_functioncysteine-type peptidase activity
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue J0V A 301
ChainResidue
AASN18
AGLY20
ALYS77
AARG79
ATYR89
AASN187
AJ0V302
AJ0V303

site_idAC2
Number of Residues8
Detailsbinding site for residue J0V A 302
ChainResidue
AGLN21
AGLN76
ALYS77
AARG79
AARG108
AJ0V301
AHOH472
AGLY20

site_idAC3
Number of Residues14
Detailsbinding site for residue J0V A 303
ChainResidue
AASN18
AGLN19
AGLY20
ALYS77
AARG79
ALYS103
ALYS106
AGLN143
ATRP184
AASN187
ATRP188
AJ0V301
AHOH407
AHOH438

site_idAC4
Number of Residues11
Detailsbinding site for residue J0V A 304
ChainResidue
AARG8
AGLY66
AALA134
ALEU160
AASN161
AHIS162
AASN190
ALYS191
ALEU209
AHOH447
AHOH451

Functional Information from PROSITE/UniProt
site_idPS00139
Number of Residues12
DetailsTHIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSS
ChainResidueDetails
AGLN19-SER30

site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAVLAVGYG
ChainResidueDetails
ALEU160-GLY170

site_idPS00640
Number of Residues20
DetailsTHIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. HWIiKNSWgenWGnkGYIlM
ChainResidueDetails
AHIS177-MET196

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: ACT_SITE => ECO:0000250
ChainResidueDetails
ACYS25
AHIS162
AASN182

225946

PDB entries from 2024-10-09

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