6PUU
Human TRPM2 bound to 8-Br-cADPR and calcium
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Transient receptor potential cation channel subfamily M member 2 | polymer | 1512 | 172280.1 | 4 | UniProt (O94759) Pfam (PF18139) Pfam (PF00520) In PDB | Homo sapiens (Human) | TRPM2, Estrogen-responsive element-associated gene 1 protein, Long transient receptor potential channel 2, LTrpC2, Transient receptor potential channel 7, TrpC7, Transient receptor potential melastatin 2 |
2 | A, B, C, D | (2R,3R,4S,5R,13R,14S,15R,16R)-24-amino-18-bromo-3,4,14,15-tetrahydroxy-7,9,11,25,26-pentaoxa-17,19,22-triaza-1-azonia-8 ,10-diphosphapentacyclo[18.3.1.1^2,5^.1^13,16^.0^17,21^]hexacosa-1(24),18,20,22-tetraene-8,10-diolate 8,10-dioxide | non-polymer | 621.2 | 4 | Chemie (CV1) | |||
3 | A, B, C, D | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) |
Sequence modifications
A, B, C, D: 1 - 1503 (UniProt: O94759)
PDB | External Database | Details |
---|---|---|
Gly -6 | - | expression tag |
Ser -5 | - | expression tag |
Gly -4 | - | expression tag |
Gly -3 | - | expression tag |
Arg -2 | - | expression tag |
Ala -1 | - | expression tag |
Thr 0 | - | expression tag |
Phe 1504 | - | expression tag |
Glu 1505 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 689120.2 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2645.1 | |
All* | Total formula weight | 691765.4 |