6PUU
Human TRPM2 bound to 8-Br-cADPR and calcium
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Transient receptor potential cation channel subfamily M member 2 | polymer | 1512 | 172280.1 | 4 | UniProt (O94759) Pfam (PF18139) Pfam (PF00520) | Homo sapiens (Human) | TRPM2, Estrogen-responsive element-associated gene 1 protein, Long transient receptor potential channel 2, LTrpC2, Transient receptor potential channel 7, TrpC7, Transient receptor potential melastatin 2 |
| 2 | E, G, I, K (A, B, C, D) | (2R,3R,4S,5R,13R,14S,15R,16R)-24-amino-18-bromo-3,4,14,15-tetrahydroxy-7,9,11,25,26-pentaoxa-17,19,22-triaza-1-azonia-8 ,10-diphosphapentacyclo[18.3.1.1^2,5^.1^13,16^.0^17,21^]hexacosa-1(24),18,20,22-tetraene-8,10-diolate 8,10-dioxide | non-polymer | 621.2 | 4 | Chemie (CV1) | |||
| 3 | F, H, J, L (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) |
Sequence modifications
A, B, C, D: 1 - 1503 (UniProt: O94759)
| PDB | External Database | Details |
|---|---|---|
| Gly -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Arg -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Thr 0 | - | expression tag |
| Phe 1504 | - | expression tag |
| Glu 1505 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 689120.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2645.1 | |
| All* | Total formula weight | 691765.4 |
