6PTS

NMR data-driven model of KRas-GMPPNP:RBD-CRD complex tethered to a nanodisc (state A)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, C)	Apolipoprotein A-I	polymer	198	23080.1	2	UniProt (P02647) Pfam (PF01442)	Homo sapiens (Human)	Membrane Scaffold Protein, ApoA-I, Apolipoprotein A1
2	C (B)	GTPase KRas	polymer	185	21116.1	1	UniProt (P01116) Pfam (PF00071)	Homo sapiens (Human)	K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
3	D (D)	RAF proto-oncogene serine/threonine-protein kinase	polymer	132	15266.9	1	UniProt (P04049) Pfam (PF02196) Pfam (PF00130)	Homo sapiens (Human)	Proto-oncogene c-RAF,cRaf,Raf-1
4	AA, AC, BA, BB, BC... (C, D, B, A)	1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		787.1	64	Chemie (PCW)
5	AB, CC, DC, EC, FC... (C, D, A, B)	O-[(S)-({(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propyl}oxy)(hydroxy)phosphoryl]-L-serine	non-polymer		788.0	16	Chemie (17F) PubChem (16219821) PubChem (58556791) PubChem (57369815) PubChem (125750) PubChem (3451126) PubChem (5830256) PubChem (6438639) PubChem (124226306) PubChem (145954209) PubChem (15409351) PubChem (99650225) PubChem (122607770) PubChem (124629033) PubChem (9547077) PubChem (9547078) PubChem (9898005)
6	QB (B)	PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER	non-polymer		522.2	1	Chemie (GNP)
7	RB (B)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG) PubChem (888)
8	IC, JC (D)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

D: 356 - 487 (UniProt: P04049)

PDB	External Database	Details
Gln 403	His 103	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	82543.3
Non-Polymers*	Number of molecules	84
	Total formula weight	63661.8
All*	Total formula weight	146205.1

*Water molecules are not included.