6PTS
NMR data-driven model of KRas-GMPPNP:RBD-CRD complex tethered to a nanodisc (state A)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006869 | biological_process | lipid transport |
| A | 0008289 | molecular_function | lipid binding |
| A | 0042157 | biological_process | lipoprotein metabolic process |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0000165 | biological_process | MAPK cascade |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0001889 | biological_process | liver development |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0003925 | molecular_function | G protein activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005741 | cellular_component | mitochondrial outer membrane |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005925 | cellular_component | focal adhesion |
| B | 0007165 | biological_process | signal transduction |
| B | 0007265 | biological_process | Ras protein signal transduction |
| B | 0007565 | biological_process | female pregnancy |
| B | 0008284 | biological_process | positive regulation of cell population proliferation |
| B | 0009629 | biological_process | response to gravity |
| B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| B | 0010628 | biological_process | positive regulation of gene expression |
| B | 0012505 | cellular_component | endomembrane system |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019002 | molecular_function | GMP binding |
| B | 0019003 | molecular_function | GDP binding |
| B | 0019221 | biological_process | cytokine-mediated signaling pathway |
| B | 0030275 | molecular_function | LRR domain binding |
| B | 0035900 | biological_process | response to isolation stress |
| B | 0043495 | molecular_function | protein-membrane adaptor activity |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0046579 | biological_process | positive regulation of Ras protein signal transduction |
| B | 0051384 | biological_process | response to glucocorticoid |
| B | 0051385 | biological_process | response to mineralocorticoid |
| B | 0051450 | biological_process | myoblast proliferation |
| B | 0060038 | biological_process | cardiac muscle cell proliferation |
| B | 2000774 | biological_process | positive regulation of cellular senescence |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006869 | biological_process | lipid transport |
| C | 0008289 | molecular_function | lipid binding |
| C | 0042157 | biological_process | lipoprotein metabolic process |
| D | 0007165 | biological_process | signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue PCW A 401 |
| Chain | Residue |
| C | PCW610 |
| C | PCW613 |
| C | PCW618 |
| D | PCW502 |
| D | PCW508 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue PCW A 402 |
| Chain | Residue |
| B | PCW210 |
| C | PCW611 |
| D | PCW507 |
| D | 17F513 |
| A | PCW413 |
| B | GLN131 |
| B | PHE141 |
| B | ILE142 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue PCW A 403 |
| Chain | Residue |
| A | PCW406 |
| B | PCW201 |
| B | PCW205 |
| B | PCW207 |
| B | PCW209 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue PCW A 404 |
| Chain | Residue |
| A | PCW407 |
| B | PCW210 |
| C | 17F631 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue PCW A 405 |
| Chain | Residue |
| A | PCW414 |
| B | PCW203 |
| D | 17F512 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue PCW A 406 |
| Chain | Residue |
| A | ASP246 |
| A | PCW403 |
| B | PCW209 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue PCW A 407 |
| Chain | Residue |
| A | PCW404 |
| B | PCW210 |
| B | PCW211 |
| C | 17F631 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue PCW A 408 |
| Chain | Residue |
| A | 17F409 |
| D | 17F511 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue 17F A 409 |
| Chain | Residue |
| A | PCW408 |
| B | LYS169 |
| B | LYS172 |
| B | PCW202 |
| D | PCW504 |
| D | 17F511 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue 17F A 410 |
| Chain | Residue |
| C | PCW610 |
| D | PCW502 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue PCW A 411 |
| Chain | Residue |
| A | PCW415 |
| A | PCW416 |
| B | PCW202 |
| C | PCW616 |
| C | 17F630 |
| D | PCW515 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue PCW A 412 |
| Chain | Residue |
| A | PCW414 |
| B | PCW203 |
| C | PCW604 |
| C | PCW623 |
| C | PCW624 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue PCW A 413 |
| Chain | Residue |
| A | PHE214 |
| A | PCW402 |
| A | PCW415 |
| C | PCW611 |
| C | PCW616 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue PCW A 414 |
| Chain | Residue |
| A | PCW405 |
| A | PCW412 |
| C | PCW604 |
| C | PCW613 |
| C | PCW623 |
| C | PCW624 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue PCW A 415 |
| Chain | Residue |
| A | PCW411 |
| A | PCW413 |
| C | PCW615 |
| C | PCW616 |
| C | PCW617 |
| D | PCW515 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue PCW A 416 |
| Chain | Residue |
| A | PCW411 |
| C | PCW616 |
| C | 17F630 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue PCW A 417 |
| Chain | Residue |
| C | PCW603 |
| C | PCW605 |
| C | PCW610 |
| C | PCW621 |
| C | PCW622 |
| D | 17F511 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue PCW C 601 |
| Chain | Residue |
| C | LYS451 |
| C | TYR455 |
| C | PCW602 |
| C | 17F626 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue PCW C 602 |
| Chain | Residue |
| B | 17F214 |
| C | PHE459 |
| C | LYS462 |
| C | PCW601 |
| C | 17F626 |
| C | 17F629 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue PCW C 603 |
| Chain | Residue |
| A | PCW417 |
| C | PCW604 |
| C | 17F628 |
| D | PCW515 |
| D | PCW516 |
| site_id | AE3 |
| Number of Residues | 11 |
| Details | binding site for residue PCW C 604 |
| Chain | Residue |
| C | PCW624 |
| C | 17F627 |
| C | 17F628 |
| D | PCW509 |
| D | 17F514 |
| A | PCW412 |
| A | PCW414 |
| B | 17F213 |
| C | PCW603 |
| C | PCW606 |
| C | PCW622 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue PCW C 605 |
| Chain | Residue |
| A | PCW417 |
| C | PCW610 |
| C | PCW612 |
| C | PCW618 |
| C | 17F630 |
| D | 17F511 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue PCW C 606 |
| Chain | Residue |
| B | 17F215 |
| C | PCW604 |
| C | PCW608 |
| C | PCW624 |
| C | 17F627 |
| C | 17F628 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue PCW C 607 |
| Chain | Residue |
| C | PCW608 |
| C | PCW624 |
| C | 17F626 |
| C | 17F629 |
| site_id | AE7 |
| Number of Residues | 9 |
| Details | binding site for residue PCW C 608 |
| Chain | Residue |
| B | PCW206 |
| B | PCW207 |
| B | 17F214 |
| C | PCW606 |
| C | PCW607 |
| C | PCW614 |
| C | PCW619 |
| C | 17F626 |
| C | 17F632 |
| site_id | AE8 |
| Number of Residues | 1 |
| Details | binding site for residue PCW C 609 |
| Chain | Residue |
| C | 17F631 |
| site_id | AE9 |
| Number of Residues | 8 |
| Details | binding site for residue PCW C 610 |
| Chain | Residue |
| A | PCW401 |
| A | 17F410 |
| A | PCW417 |
| C | PCW605 |
| C | PCW612 |
| C | PCW618 |
| C | PCW622 |
| C | PCW623 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue PCW C 611 |
| Chain | Residue |
| A | PCW402 |
| A | PCW413 |
| C | PCW617 |
| C | PCW625 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue PCW C 612 |
| Chain | Residue |
| C | PCW605 |
| C | PCW610 |
| C | PCW618 |
| D | 17F511 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue PCW C 613 |
| Chain | Residue |
| A | PCW401 |
| A | PCW414 |
| C | PCW618 |
| C | PCW622 |
| C | PCW623 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue PCW C 614 |
| Chain | Residue |
| B | PCW206 |
| B | PCW207 |
| C | PCW608 |
| C | 17F632 |
| site_id | AF5 |
| Number of Residues | 7 |
| Details | binding site for residue PCW C 615 |
| Chain | Residue |
| A | PCW415 |
| C | PCW616 |
| C | PCW617 |
| C | PCW625 |
| D | PCW503 |
| D | PCW515 |
| D | PCW516 |
| site_id | AF6 |
| Number of Residues | 5 |
| Details | binding site for residue PCW C 616 |
| Chain | Residue |
| A | PCW411 |
| A | PCW413 |
| A | PCW415 |
| A | PCW416 |
| C | PCW615 |
| site_id | AF7 |
| Number of Residues | 7 |
| Details | binding site for residue PCW C 617 |
| Chain | Residue |
| A | PCW415 |
| C | PCW611 |
| C | PCW615 |
| C | PCW621 |
| C | PCW625 |
| D | PCW503 |
| D | 17F513 |
| site_id | AF8 |
| Number of Residues | 5 |
| Details | binding site for residue PCW C 618 |
| Chain | Residue |
| A | PCW401 |
| C | PCW605 |
| C | PCW610 |
| C | PCW612 |
| C | PCW613 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue PCW C 619 |
| Chain | Residue |
| C | PCW608 |
| C | PCW620 |
| C | 17F632 |
| site_id | AG1 |
| Number of Residues | 5 |
| Details | binding site for residue PCW C 620 |
| Chain | Residue |
| B | 17F215 |
| C | PCW619 |
| C | PCW621 |
| C | 17F631 |
| C | 17F632 |
| site_id | AG2 |
| Number of Residues | 8 |
| Details | binding site for residue PCW C 621 |
| Chain | Residue |
| A | PCW417 |
| C | PCW617 |
| C | PCW620 |
| C | PCW625 |
| C | 17F627 |
| C | 17F628 |
| D | PCW506 |
| D | PCW516 |
| site_id | AG3 |
| Number of Residues | 6 |
| Details | binding site for residue PCW C 622 |
| Chain | Residue |
| A | PCW417 |
| C | PCW604 |
| C | PCW610 |
| C | PCW613 |
| C | PCW623 |
| D | 17F511 |
| site_id | AG4 |
| Number of Residues | 6 |
| Details | binding site for residue PCW C 623 |
| Chain | Residue |
| A | PCW412 |
| A | PCW414 |
| C | PCW610 |
| C | PCW613 |
| C | PCW622 |
| C | PCW624 |
| site_id | AG5 |
| Number of Residues | 6 |
| Details | binding site for residue PCW C 624 |
| Chain | Residue |
| A | PCW412 |
| A | PCW414 |
| C | PCW604 |
| C | PCW606 |
| C | PCW607 |
| C | PCW623 |
| site_id | AG6 |
| Number of Residues | 5 |
| Details | binding site for residue PCW C 625 |
| Chain | Residue |
| C | PCW611 |
| C | PCW615 |
| C | PCW617 |
| C | PCW621 |
| D | PCW516 |
| site_id | AG7 |
| Number of Residues | 6 |
| Details | binding site for residue 17F C 626 |
| Chain | Residue |
| B | 17F214 |
| C | PCW601 |
| C | PCW602 |
| C | PCW607 |
| C | PCW608 |
| C | 17F629 |
| site_id | AG8 |
| Number of Residues | 6 |
| Details | binding site for residue 17F C 627 |
| Chain | Residue |
| B | 17F213 |
| B | 17F215 |
| C | PCW604 |
| C | PCW606 |
| C | PCW621 |
| C | 17F628 |
| site_id | AG9 |
| Number of Residues | 8 |
| Details | binding site for residue 17F C 628 |
| Chain | Residue |
| B | 17F213 |
| B | 17F215 |
| C | PCW603 |
| C | PCW604 |
| C | PCW606 |
| C | PCW621 |
| C | 17F627 |
| D | PCW506 |
| site_id | AH1 |
| Number of Residues | 4 |
| Details | binding site for residue 17F C 629 |
| Chain | Residue |
| C | TRP463 |
| C | PCW602 |
| C | PCW607 |
| C | 17F626 |
| site_id | AH2 |
| Number of Residues | 5 |
| Details | binding site for residue 17F C 630 |
| Chain | Residue |
| A | PCW411 |
| A | PCW416 |
| C | TYR591 |
| C | ASN596 |
| C | PCW605 |
| site_id | AH3 |
| Number of Residues | 5 |
| Details | binding site for residue 17F C 631 |
| Chain | Residue |
| A | PCW404 |
| A | PCW407 |
| B | PCW211 |
| C | PCW609 |
| C | PCW620 |
| site_id | AH4 |
| Number of Residues | 7 |
| Details | binding site for residue 17F C 632 |
| Chain | Residue |
| B | PCW205 |
| B | PCW207 |
| B | 17F215 |
| C | PCW608 |
| C | PCW614 |
| C | PCW619 |
| C | PCW620 |
| site_id | AH5 |
| Number of Residues | 4 |
| Details | binding site for residue PCW B 201 |
| Chain | Residue |
| A | PCW403 |
| B | PCW205 |
| B | PCW207 |
| B | PCW209 |
| site_id | AH6 |
| Number of Residues | 4 |
| Details | binding site for residue PCW B 202 |
| Chain | Residue |
| A | 17F409 |
| A | PCW411 |
| B | ARG135 |
| D | PCW504 |
| site_id | AH7 |
| Number of Residues | 4 |
| Details | binding site for residue PCW B 203 |
| Chain | Residue |
| A | PCW405 |
| A | PCW412 |
| B | PCW204 |
| B | PCW208 |
| site_id | AH8 |
| Number of Residues | 7 |
| Details | binding site for residue PCW B 204 |
| Chain | Residue |
| B | PCW203 |
| B | PCW208 |
| B | PCW212 |
| B | 17F214 |
| D | PCW502 |
| D | 17F512 |
| D | 17F514 |
| site_id | AH9 |
| Number of Residues | 8 |
| Details | binding site for residue PCW B 205 |
| Chain | Residue |
| A | PCW403 |
| B | PCW201 |
| B | PCW206 |
| B | PCW207 |
| B | PCW212 |
| B | 17F213 |
| B | 17F214 |
| C | 17F632 |
| site_id | AI1 |
| Number of Residues | 7 |
| Details | binding site for residue PCW B 206 |
| Chain | Residue |
| B | PCW205 |
| B | PCW207 |
| B | PCW209 |
| B | 17F213 |
| C | PCW608 |
| C | PCW614 |
| D | GLU474 |
| site_id | AI2 |
| Number of Residues | 8 |
| Details | binding site for residue PCW B 207 |
| Chain | Residue |
| A | PCW403 |
| B | PCW201 |
| B | PCW205 |
| B | PCW206 |
| B | PCW209 |
| C | PCW608 |
| C | PCW614 |
| C | 17F632 |
| site_id | AI3 |
| Number of Residues | 5 |
| Details | binding site for residue PCW B 208 |
| Chain | Residue |
| B | PCW203 |
| B | PCW204 |
| B | PCW212 |
| B | 17F214 |
| D | 17F512 |
| site_id | AI4 |
| Number of Residues | 6 |
| Details | binding site for residue PCW B 209 |
| Chain | Residue |
| A | PCW403 |
| A | PCW406 |
| B | PCW201 |
| B | PCW206 |
| B | PCW207 |
| B | 17F215 |
| site_id | AI5 |
| Number of Residues | 11 |
| Details | binding site for residue PCW B 210 |
| Chain | Residue |
| A | PCW402 |
| A | PCW404 |
| A | PCW407 |
| B | GLY151 |
| B | VAL152 |
| B | ASP153 |
| B | PCW211 |
| D | PCW503 |
| D | PCW506 |
| D | PCW507 |
| D | 17F513 |
| site_id | AI6 |
| Number of Residues | 6 |
| Details | binding site for residue PCW B 211 |
| Chain | Residue |
| A | PCW407 |
| B | PCW210 |
| C | 17F631 |
| D | THR445 |
| D | PCW505 |
| D | PCW506 |
| site_id | AI7 |
| Number of Residues | 8 |
| Details | binding site for residue PCW B 212 |
| Chain | Residue |
| B | PCW204 |
| B | PCW205 |
| B | PCW208 |
| B | 17F213 |
| B | 17F214 |
| D | LYS457 |
| D | 17F512 |
| D | 17F514 |
| site_id | AI8 |
| Number of Residues | 7 |
| Details | binding site for residue 17F B 213 |
| Chain | Residue |
| B | PCW205 |
| B | PCW206 |
| B | PCW212 |
| C | PCW604 |
| C | 17F627 |
| C | 17F628 |
| D | PCW505 |
| site_id | AI9 |
| Number of Residues | 7 |
| Details | binding site for residue 17F B 214 |
| Chain | Residue |
| B | PCW204 |
| B | PCW205 |
| B | PCW208 |
| B | PCW212 |
| C | PCW602 |
| C | PCW608 |
| C | 17F626 |
| site_id | AJ1 |
| Number of Residues | 6 |
| Details | binding site for residue 17F B 215 |
| Chain | Residue |
| B | PCW209 |
| C | PCW606 |
| C | PCW620 |
| C | 17F627 |
| C | 17F628 |
| C | 17F632 |
| site_id | AJ2 |
| Number of Residues | 17 |
| Details | binding site for residue GNP B 216 |
| Chain | Residue |
| B | GLY13 |
| B | GLY15 |
| B | LYS16 |
| B | SER17 |
| B | ALA18 |
| B | VAL29 |
| B | TYR32 |
| B | ASP33 |
| B | THR35 |
| B | THR58 |
| B | ASN116 |
| B | LYS117 |
| B | LEU120 |
| B | SER145 |
| B | ALA146 |
| B | LYS147 |
| B | MG217 |
| site_id | AJ3 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 217 |
| Chain | Residue |
| B | SER17 |
| B | ASP33 |
| B | THR35 |
| B | GNP216 |
| site_id | AJ4 |
| Number of Residues | 4 |
| Details | binding site for residue PCW D 501 |
| Chain | Residue |
| D | CYS455 |
| D | GLN456 |
| D | PCW509 |
| D | 17F511 |
| site_id | AJ5 |
| Number of Residues | 5 |
| Details | binding site for residue PCW D 502 |
| Chain | Residue |
| A | PCW401 |
| A | 17F410 |
| B | PCW204 |
| D | PCW508 |
| D | 17F512 |
| site_id | AJ6 |
| Number of Residues | 10 |
| Details | binding site for residue PCW D 503 |
| Chain | Residue |
| B | TYR157 |
| B | ARG161 |
| B | PCW210 |
| C | PCW615 |
| C | PCW617 |
| D | LYS448 |
| D | PCW504 |
| D | PCW506 |
| D | PCW507 |
| D | PCW510 |
| site_id | AJ7 |
| Number of Residues | 6 |
| Details | binding site for residue PCW D 504 |
| Chain | Residue |
| A | 17F409 |
| B | LYS165 |
| B | GLU168 |
| B | PCW202 |
| D | PCW503 |
| D | PCW510 |
| site_id | AJ8 |
| Number of Residues | 7 |
| Details | binding site for residue PCW D 505 |
| Chain | Residue |
| B | PCW211 |
| B | 17F213 |
| D | PHE458 |
| D | PCW506 |
| D | PCW509 |
| D | PCW510 |
| D | 17F513 |
| site_id | AJ9 |
| Number of Residues | 10 |
| Details | binding site for residue PCW D 506 |
| Chain | Residue |
| B | PCW210 |
| B | PCW211 |
| C | PCW621 |
| C | 17F628 |
| D | PHE446 |
| D | LEU447 |
| D | PCW503 |
| D | PCW505 |
| D | 17F513 |
| D | PCW516 |
| site_id | AK1 |
| Number of Residues | 7 |
| Details | binding site for residue PCW D 507 |
| Chain | Residue |
| A | PCW402 |
| B | THR158 |
| B | GLU162 |
| B | LYS165 |
| B | PCW210 |
| D | PCW503 |
| D | 17F513 |
| site_id | AK2 |
| Number of Residues | 4 |
| Details | binding site for residue PCW D 508 |
| Chain | Residue |
| A | PCW401 |
| D | PCW502 |
| D | 17F512 |
| D | 17F514 |
| site_id | AK3 |
| Number of Residues | 7 |
| Details | binding site for residue PCW D 509 |
| Chain | Residue |
| C | PCW604 |
| D | PHE451 |
| D | PHE458 |
| D | PCW501 |
| D | PCW505 |
| D | PCW510 |
| D | 17F514 |
| site_id | AK4 |
| Number of Residues | 8 |
| Details | binding site for residue PCW D 510 |
| Chain | Residue |
| D | PHE451 |
| D | PCW503 |
| D | PCW504 |
| D | PCW505 |
| D | PCW509 |
| D | 17F513 |
| D | PCW515 |
| D | PCW516 |
| site_id | AK5 |
| Number of Residues | 7 |
| Details | binding site for residue 17F D 511 |
| Chain | Residue |
| A | PCW408 |
| A | 17F409 |
| A | PCW417 |
| C | PCW605 |
| C | PCW612 |
| C | PCW622 |
| D | PCW501 |
| site_id | AK6 |
| Number of Residues | 6 |
| Details | binding site for residue 17F D 512 |
| Chain | Residue |
| A | PCW405 |
| B | PCW204 |
| B | PCW208 |
| B | PCW212 |
| D | PCW502 |
| D | PCW508 |
| site_id | AK7 |
| Number of Residues | 10 |
| Details | binding site for residue 17F D 513 |
| Chain | Residue |
| A | PCW402 |
| B | GLY151 |
| B | ASP154 |
| B | PCW210 |
| C | PCW617 |
| D | PCW505 |
| D | PCW506 |
| D | PCW507 |
| D | PCW510 |
| D | PCW516 |
| site_id | AK8 |
| Number of Residues | 6 |
| Details | binding site for residue 17F D 514 |
| Chain | Residue |
| B | PCW204 |
| B | PCW212 |
| C | PCW604 |
| D | GLN456 |
| D | PCW508 |
| D | PCW509 |
| site_id | AK9 |
| Number of Residues | 6 |
| Details | binding site for residue PCW D 515 |
| Chain | Residue |
| A | PCW411 |
| A | PCW415 |
| C | PCW603 |
| C | PCW615 |
| D | PCW510 |
| D | PCW516 |
| site_id | AL1 |
| Number of Residues | 8 |
| Details | binding site for residue PCW D 516 |
| Chain | Residue |
| C | PCW603 |
| C | PCW615 |
| C | PCW621 |
| C | PCW625 |
| D | PCW506 |
| D | PCW510 |
| D | 17F513 |
| D | PCW515 |
| site_id | AL2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 517 |
| Chain | Residue |
| D | CYS452 |
| D | CYS455 |
| D | HIS473 |
| D | CYS476 |
| site_id | AL3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 518 |
| Chain | Residue |
| D | HIS439 |
| D | CYS465 |
| D | CYS468 |
| D | CYS484 |
Functional Information from PROSITE/UniProt
| site_id | PS00479 |
| Number of Residues | 46 |
| Details | ZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HnFarktflklaf.CdiCqkfLlngfr.....CqtCgykfHehCstkvptm..C |
| Chain | Residue | Details |
| D | HIS439-CYS484 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Repeat: {"description":"3; half-length"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | Repeat: {"description":"9; half-length"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Methionine sulfoxide","evidences":[{"source":"PubMed","id":"12576517","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) lysine","evidences":[{"source":"PubMed","id":"8261628","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Cysteine methyl ester","evidences":[{"source":"PubMed","id":"27791178","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TAR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TB5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"29239724","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"N6-palmitoyl lysine","evidences":[{"source":"PubMed","id":"29239724","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"N6-palmitoyl lysine","evidences":[{"source":"PubMed","id":"29239724","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-farnesyl cysteine","evidences":[{"source":"PubMed","id":"27791178","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24415755","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5TAR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TB5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"30442762","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 75 |
| Details | Domain: {"description":"RBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00262","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 46 |
| Details | Zinc finger: {"description":"Phorbol-ester/DAG-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00226","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
