6PT5

Crystal Structure of Class D Beta-lactamase OXA-48 with Cefoxitin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Class D Carbapenemase OXA-48	polymer	263	30826.9	4	UniProt (A0A482LRD5) Pfam (PF00905) UniProt (by SIFTS) (Q6XEC0)	Klebsiella pneumoniae
2	E, G (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
3	F, H, I, J (A, B, C, D)	(2R)-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid	non-polymer		368.4	4	Chemie (1S7)
4	K, L, M, N (A, B, C, D)	water	water		18.0	129	Chemie (HOH)

Sequence modifications

A, B, C, D: 25 - 265 (UniProt: A0A482LRD5)

PDB	External Database	Details
Met 3	-	initiating methionine
Lys 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
Met 11	-	expression tag
His 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
Glu 18	-	expression tag
Asn 19	-	expression tag
Leu 20	-	expression tag
Tyr 21	-	expression tag
Phe 22	-	expression tag
Gln 23	-	expression tag
Gly 24	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	123307.5
Non-Polymers*	Number of molecules	6
	Total formula weight	1544.6
All*	Total formula weight	124852.1

*Water molecules are not included.